Imidazopyridazinone and imidazopyridone derivatives, the preparation thereof and their use as pharmaceutical compositions

ABSTRACT

The present invention relates to substituted imidazo-pyridinones and imidazo-pyridazinones of general formula 
                         
wherein Y and R 1  to R 4  are defined as in claim  1 , the tautomers, enantiomers, diastereomers, the mixtures thereof and the salts thereof, which have valuable pharmacological properties, particularly an inhibiting effect on the activity of the enzyme dipeptidylpeptidase-IV (DPP-IV).

RELATED APPLICATIONS

This application is a divisional of U.S. application Ser. No. 10/865,719, filed Jun. 10, 2004, now allowed, which claims benefit of U.S. Ser. No. PV 60/487,309, filed Jul. 15, 2003, and claims priority to German Application No. DE 10327439.1 filed Jun. 18, 2003, each of which is hereby incorporated by reference in its entirety.

The present invention relates to new substituted imidazopyridazinones and imidazopyridones of general formula

the tautomers, the enantiomers, the diastereomers, the mixtures thereof, the prodrugs thereof and the salts thereof, particularly the physiologically acceptable salts thereof with inorganic or organic acids or bases which have valuable pharmacological properties, particularly an inhibiting effect on the activity of the enzyme dipeptidylpeptidase-IV (DPP-IV), the preparation thereof, the use thereof for the prevention or treatment of diseases or conditions associated with an increased DPP-IV activity or capable of being prevented or alleviated by reducing the DPP-IV activity, particularly type I or type II diabetes mellitus, the pharmaceutical compositions containing a compound of general formula (I) or a physiologically acceptable salt thereof as well as processes for the preparation thereof.

The present invention thus relates to the above compounds of general formula I which have valuable pharmacological properties, the pharmaceutical compositions containing the pharmacologically effective compounds, the use thereof and processes for the preparation thereof.

In the above general formula I

R¹ denotes a C₁₋₃-alkyl group substituted by a group R_(a), where

-   -   R_(a) denotes a 3,4-dihydro-quinolinyl,         3,4-dihydro-isoquinolinyl, 1,4-dihydro-quinazolinyl,         3,4-dihydro-quinazolinyl, 1H-benzo[d][1,2]oxazinyl,         4H-benzo[e][1,3]-oxazinyl, 4H-benzo[d][1,3]oxazinyl or         2H-benzo[1,4]oxazinyl group, wherein in each case         -   in the benzo moiety one to three methyne groups may each be             replaced by a nitrogen atom and in the heterocyclyl moiety a             methylene group may be replaced by a carbonyl group,     -   a 4H-benzo[e][1,3]thiazinyl, 4H-benzo[d][1,3]thiazinyl or         2H-benzo[1,4]thiazinyl group wherein in each case         -   in the benzo moiety one to three methyne groups may each be             replaced by a nitrogen atom and in the heterocyclyl moiety a             methylene group may be replaced by a carbonyl group and the             sulphur atom may be replaced by a sulphinyl or sulphonyl             group,     -   a 2-oxo-2H-benzo[e][1,3]oxazinyl or         2,2-dioxo-1H-benzo[c][1,2]thiazinyl group wherein in each case         in the benzo moiety         -   one to three methyne groups may each be replaced by a             nitrogen atom,     -   a 2,3-dihydro-1H-benzo[e][1,4]diazepinyl,         4,5-dihydro-3H-benzo[b][1,4]diazepinyl or         5-oxo-4,5-dihydro-3H-benzo[e][1,4]diazepinyl group wherein in         each case         -   in the benzo moiety one to three methyne groups may each be             replaced by a nitrogen atom and in the heterocyclyl moiety a             methylene group may be replaced by a carbonyl group,     -   a 2,3-dihydro-benzo[f][1,4]oxazepinyl or         2,3-dihydro-benzo[b][1,4]oxazepinyl group wherein in each case         -   in the benzo moiety one to three methyne groups may each be             replaced by a nitrogen atom and in the heterocyclyl moiety a             methylene group may be replaced by a carbonyl group,     -   a 2,3-dihydro-benzo[b][1,4]thiazepinyl or         2,3-dihydro-benzo[f][1,4]thiazepinyl group wherein in each case         -   in the benzo moiety one to three methyne groups may each be             replaced by a nitrogen atom and in the heterocyclyl moiety a             methylene group may be replaced by a carbonyl group and the             sulphur atom may be replaced by a sulphinyl or sulphonyl             group,     -   a 5-oxo-4,5-dihydro-benzo[f][1,3,4]oxadiazepinyl group wherein         -   in the benzo moiety one to three methyne groups may each be             replaced by a nitrogen atom,     -   a 11H-dibenzo[b,e]azepinyl or 5H-dibenzo[a,d]cycloheptenyl group         wherein in each case         -   in the benzo moiety one to three methyne groups may each be             replaced by a nitrogen atom and the methylene group in the             heterocyclyl moiety may be replaced by an oxygen or sulphur             atom, a carbonyl, sulphinyl or sulphonyl group or by an             imino group substituted by R_(x), where             -   R_(x) denotes a hydrogen atom or a C₁₋₄-alkyl,                 C₂₋₄-alkenyl, C₂₋₄-alkynyl, C₃₋₆-cycloalkyl,                 C₃₋₆-cycloalkyl-C₁₋₃-alkyl, aryl, aryl-C₁₋₃-alkyl,                 hydroxy-C₂₋₄-alkyl, C₁₋₃-alkyloxy-C₂₋₄-alkyl,                 C₃₋₆-cycloalkyloxy-C₂₋₄-alkyl, amino-C₂₋₄-alkyl,                 C₁₋₃-alkylamino-C₂₋₄-alkyl,                 di-(C₁₋₃-alkyl)-amino-C₂₋₄-alkyl, C₁₋₃-alkyl-carbonyl,                 C₁₋₃-alkyloxy-carbonyl,                 C₁₋₃-alkyloxy-carbonyl-C₁₋₃-alkyl, aryl-carbonyl,                 C₁₋₃-alkyl-sulphonyl or aryl-sulphonyl group,     -   a phenanthridinyl group wherein         -   in the benzo moiety one to three methyne groups may each be             replaced by a nitrogen atom, and     -   a 1,2,3,4-tetrahydro-phenanthridinyl,         1,2,3,4,4a,10b-hexahydro-phenanthridinyl,         2,3-dihydro-1H-4-aza-cyclopenta[a]naphthyl or a         8,9,10,11-tetrahydro-7H-6-aza-cyclohepta[a]naphthyl group         wherein in each case         -   in the benzo moiety one to three methyne groups may each be             replaced by a nitrogen atom and one or two methylene groups             may each be replaced by an oxygen atom or a carbonyl group,             while, if two methylene groups are each replaced by an             oxygen atom, the oxygen atoms must be separated from one             another by at least two methylene units,     -   a phenanthrenyl group wherein         -   in each case one to three of the methyne groups in position             1 to 4 and 5 to 8 may each be replaced by a nitrogen atom,     -   a 1,2,3,4-tetrahydro-phenanthrenyl or a         1,2,3,4,5,6,7,8-octahydro-phenanthrenyl group wherein         -   in each case one or two of the methylene groups in position             1 to 4 and 5 to 8 may each be replaced by an oxygen atom or             a carbonyl group, while, if two methylene groups are each             replaced by an oxygen atom, the oxygen atoms must be             separated from one another by at least two methylene units,     -   a 5H-benzo[e]pyrrolo[1,2-a][1,4]diazepinyl,         thieno[3,2-b][1,4]benzoxazepinyl, 5H-dibenzo[d,f][1,3]diazepinyl         or a 5-oxa-7-aza-dibenzo[a,c]cycloheptenyl group wherein in each         case         -   in the benzo moiety one to three methyne groups may each be             replaced by a nitrogen atom,     -   a naphtho[1,2-d]oxazolyl, naphtho[2,1-d]oxazolyl,         naphtho[1,2-d]thiazolyl, naphtho[2,1-d]thiazolyl,         naphtho[1,2-d]imidazolyl, naphtho[1,2-b]furanyl or         naphtho[2,1-b]furanyl group wherein in each case         -   in the naphthyl moiety one to three methyne groups may each             be replaced by a nitrogen atom,     -   or a furo[3,2-c]isoquinolinyl, pyrazolo[1,5-c]quinazolinyl or         1H-perimidinyl group,     -   while the methylene and methyne groups of the above mentioned         radicals R_(a) may be substituted by the groups R¹⁰ to R¹³ and         additionally by a C₁₋₃-alkyl group and the imino groups of the         above mentioned radicals R_(a) may be substituted by the groups         R_(x) as hereinbefore defined and         -   R¹⁰ denotes a hydrogen atom,         -   a fluorine, chlorine, bromine or iodine atom,         -   a C₁₋₄-alkyl, hydroxy, or C₁₋₄-alkyloxy group,         -   a nitro, amino, C₁₋₃-alkylamino, di-(C₁₋₃-alkyl)amino,             cyano-C₁₋₃-alkylamino,             N-(cyano-C₁₋₃-alkyl)-N—(C₁₋₃-alkyl)-amino,             C₁₋₃-alkyloxy-carbonyl-C₁₋₃-alkylamino, pyrrolidin-1-yl,             piperidin-1-yl, morpholin-4-yl, piperazin-1-yl, or             4-(C₁₋₃-alkyl)-piperazin-1-yl group,         -   a C₁₋₃-alkyl-carbonylamino, arylcarbonylamino,             aryl-C₁₋₃-alkyl-carbonylamino, C₁₋₃-alkyloxy-carbonylamino,             aminocarbonylamino, C₁₋₃-alkylaminocarbonylamino,             di-(C₁₋₃-alkyl)aminocarbonylamino,             pyrrolidin-1-yl-carbonylamino, piperidin-1-yl-carbonylamino,             morpholin-4-yl-carbonylamino, piperazin-1-yl-carbonylamino             or 4-(C₁₋₃-alkyl)-piperazin-1-yl-carbonylamino,             C₁₋₃-alkyl-sulphonylamino, bis-(C₁₋₃-alkylsulphonyl)-amino,             aminosulphonylamino, C₁₋₃-alkylamino-sulphonylamino,             di-(C₁₋₃-alkyl)amino-sulphonylamino,             pyrrolidin-1-yl-sulphonylamino,             piperidin-1-yl-sulphonylamino,             morpholin-4-yl-sulphonylamino, piperazin-1-yl-sulphonylamino             or 4-(C₁₋₃-alkyl)-piperazin-1-yl-sulphonylamino,             (C₁₋₃-alkylamino)thiocarbonylamino,             (C₁₋₃-alkyloxy-carbonylamino)carbonylamino,             arylsulphonylamino or aryl-C₁₋₃-alkyl-sulphonylamino group,         -   an N—(C₁₋₃-alkyl)-C₁₋₃-alkyl-carbonylamino,             N—(C₁₋₃-alkyl)-arylcarbonylamino,             N—(C₁₋₃-alkyl)-aryl-C₁₋₃-alkyl-carbonylamino,             N—(C₁₋₃-alkyl)-C₁₋₃-alkyloxy-carbonylamino,             N-(aminocarbonyl)-C₁₋₃-alkylamino,             N—(C₁₋₃-alkyl-aminocarbonyl)-C₁₋₃-alkylamino,             N—[di-(C₁₋₃-alkyl)aminocarbonyl]-C₁₋₃-alkylamino,             N—(C₁₋₃-alkyl)-C₁₋₃-alkyl-sulphonylamino,             N—(C₁₋₃-alkyl)-arylsulphonylamino, or             N—(C₁₋₃-alkyl)-aryl-C₁₋₃-alkyl-sulphonylamino group,         -   a 2-oxo-imidazolidin-1-yl, 2,4-dioxo-imidazolidin-1-yl,             2,5-dioxo-imidazolidin-1-yl or 2-oxo-hexahydropyrimidin-1-yl             group wherein the nitrogen atom in the 3 position may be             substituted in each case by a methyl or ethyl group,         -   a cyano, carboxy, C₁₋₃-alkyloxy-carbonyl, aminocarbonyl,             C₁₋₃-alkyl-aminocarbonyl, di-(C₁₋₃-alkyl)-aminocarbonyl,             pyrrolidin-1-yl-carbonyl, piperidin-1-yl-carbonyl,             morpholin-4-yl-carbonyl, piperazin-1-yl-carbonyl or             4-(C₁₋₃-alkyl)-piperazin-1-yl-carbonyl group,         -   a C₁₋₃-alkyl-carbonyl or an arylcarbonyl group,         -   a carboxy-C₁₋₃-alkyl, C₁₋₃-alkyloxy-carbonyl-C₁₋₃-alkyl,             cyano-C₁₋₃-alkyl, aminocarbonyl-C₁₋₃-alkyl,             C₁₋₃-alkyl-aminocarbonyl-C₁₋₃-alkyl,             di-(C₁₋₃-alkyl)-aminocarbonyl-C₁₋₃-alkyl,             pyrrolidin-1-yl-carbonyl-C₁₋₃-alkyl,             piperidin-1-yl-carbonyl-C₁₋₃-alkyl,             morpholin-4-yl-carbonyl-C₁₋₃-alkyl,             piperazin-1-yl-carbonyl-C₁₋₃-alkyl or             4-(C₁₋₃-alkyl)-piperazin-1-yl-carbonyl-C₁₋₃-alkyl group,         -   a carboxy-C₁₋₃-alkyloxy,             C₁₋₃-alkyloxy-carbonyl-C₁₋₃-alkyloxy, cyano-C₁₋₃-alkyloxy,             aminocarbonyl-C₁₋₃-alkyloxy,             C₁₋₃-alkyl-aminocarbonyl-C₁₋₃-alkyloxy,             di-(C₁₋₃-alkyl)-aminocarbonyl-C₁₋₃-alkyloxy,             pyrrolidin-1-yl-carbonyl-C₁₋₃-alkyloxy,             piperidin-1-yl-carbonyl-C₁₋₃-alkyloxy,             morpholin-4-yl-carbonyl-C₁₋₃-alkyloxy,             piperazin-1-yl-carbonyl-C₁₋₃-alkyloxy or             4-(C₁₋₃-alkyl)-piperazin-1-yl-carbonyl-C₁₋₃-alkyloxy group,         -   a hydroxy-C₁₋₃-alkyl, C₁₋₃-alkyloxy-C₁₋₃-alkyl,             amino-C₁₋₃-alkyl, C₁₋₃-alkylamino-C₁₋₃-alkyl,             di-(C₁₋₃-alkyl)-amino-C₁₋₃-alkyl,             pyrrolidin-1-yl-C₁₋₃-alkyl, piperidin-1-yl-C₁₋₃-alkyl,             morpholin-4-yl-C₁₋₃-alkyl, piperazin-1-yl-C₁₋₃-alkyl or             4-(C₁₋₃-alkyl)-piperazin-1-yl-C₁₋₃-alkyl group,         -   a hydroxy-C₁₋₃-alkyloxy, C₁₋₃-alkyloxy-C₁₋₃-alkyloxy,             C₁₋₃-alkylsulphanyl-C₁₋₃-alkyloxy,             C₁₋₃-alkylsulphinyl-C₁₋₃-alkyloxy,             C₁₋₃-alkylsulphonyl-C₁₋₃-alkyloxy, amino-C₁₋₃-alkyloxy,             C₁₋₃-alkylamino-C₁₋₃-alkyloxy,             di-(C₁₋₃-alkyl)-amino-C₁₋₃-alkyloxy,             pyrrolidin-1-yl-C₁₋₃-alkyloxy, piperidin-1-yl-C₁₋₃-alkyloxy,             morpholin-4-yl-C₁₋₃-alkyloxy, piperazin-1-yl-C₁₋₃-alkyloxy             or 4-(C₁₋₃-alkyl)-piperazin-1-yl-C₁₋₃-alkyloxy group,         -   a mercapto, C₁₋₃-alkylsulphanyl, C₁₋₃-alkysulphinyl,             C₁₋₃-alkylsulphonyl, C₁₋₃-alkylsulphonyloxy,             arylsulphonyloxy, trifluoromethylsulphanyl,             trifluoromethylsulphinyl or trifluoromethylsulphonyl group,         -   a sulpho, aminosulphonyl, C₁₋₃-alkyl-aminosulphonyl,             di-(C₁₋₃-alkyl)-aminosulphonyl, pyrrolidin-1-yl-sulphonyl,             piperidin-1-yl-sulphonyl, morpholin-4-yl-sulphonyl,             piperazin-1-yl-sulphonyl or             4-(C₁₋₃-alkyl)-piperazin-1-yl-sulphonyl group,         -   a methyl or methoxy group substituted by 1 to 3 fluorine             atoms,         -   an ethyl or ethoxy group substituted by 1 to 5 fluorine             atoms,         -   a C₂₋₄-alkenyl or C₂₋₄-alkynyl group,         -   a C₃₋₄-alkenyloxy or C₃₋₄-alkynyloxy group,         -   a C₃₋₆-cycloalkyl or C₃₋₆-Cycloalkyloxy group,         -   a C₃₋₆-cycloalkyl-C₁₋₃-alkyl or             C₃₋₆-cycloalkyl-C₁₋₃-alkyloxy group or         -   an aryl, aryloxy, aryl-C₁₋₃-alkyl or aryl-C₁₋₃-alkyloxy             group,         -   R¹¹ and R¹², which may be identical or different, in each             case represent a hydrogen atom, a fluorine, chlorine,             bromine or iodine atom, a C₁₋₃-alkyl, trifluoromethyl,             hydroxy, C₁₋₃-alkyloxy or cyano group, or         -   R¹¹ together with R¹², if these are bound to adjacent carbon             atoms, also denotes a methylenedioxy,             difluoromethylenedioxy, ethylenedioxy or a straight-chain             C₃₋₅-alkylene group and         -   R¹³ denotes a hydrogen atom, a fluorine, chlorine or bromine             atom, a trifluoromethyl, C₁₋₃-alkyl or C₁₋₃-alkyloxy group,             R² denotes a hydrogen, fluorine or chlorine atom,             a C₁₋₆-alkyl group,             a C₂₋₄-alkenyl group,             a C₃₋₄-alkynyl group,             a C₃₋₆-cycloalkyl group,             a C₃₋₆-cycloalkyl-C₁₋₃-alkyl group,             a tetrahydrofuran-3-yl, tetrahydropyran-3-yl,             tetrahydropyran-4-yl, tetrahydrofuranylmethyl or             tetrahydropyranylmethyl group,             an aryl group,             an aryl-C₁₋₄-alkyl group,             an aryl-C₂₋₃-alkenyl group,             an arylcarbonyl group,             an arylcarbonyl-C₁₋₂-alkyl group,             a heteroaryl group,             a heteroaryl-C₁₋₃-alkyl group,             a furanylcarbonyl, thienylcarbonyl, thiazolylcarbonyl or             pyridylcarbonyl group,             a furanylcarbonylmethyl, thienylcarbonylmethyl,             thiazolylcarbonylmethyl or pyridylcarbonylmethyl group,             a C₁₋₄-alkyl-carbonyl group,             a C₁₋₄-alkyl-carbonyl-C₁₋₂-alkyl group,             a C₃₋₆-cycloalkyl-carbonyl group,             a C₃₋₆-cycloalkyl-carbonyl-C₁₋₂-alkyl group,             an aryl-A or aryl-A-C₁₋₃-alkyl group, where A denotes an             oxygen or sulphur atom, an imino, C₁₋₃-alkylimino, sulphinyl             or sulphonyl group,             a group R_(b), where     -   R_(b) denotes a cyano, carboxy, C₁₋₃-alkyloxy-carbonyl,         aminocarbonyl, C₁₋₃-alkylamino-carbonyl,         di-(C₁₋₃-alkyl)-amino-carbonyl, pyrrolidin-1-ylcarbonyl,         piperidin-1-ylcarbonyl, morpholin-4-ylcarbonyl,         piperazin-1-ylcarbonyl, 4-methylpiperazin-1-ylcarbonyl,         4-ethylpiperazin-1-ylcarbonyl, hydroxy, mercapto, C₁₋₃-alkyloxy,         C₁₋₃-alkylsulphenyl, C₁₋₃-alkylsulphinyl, C₁₋₃-alkylsulphonyl,         amino, C₁₋₃-alkylamino, di-(C₁₋₃-alkyl)-amino, pyrrolidin-1-yl,         piperidin-1-yl, morpholin-4-yl, piperazin-1-yl,         4-methyl-piperazin-1-yl or 4-ethyl-piperazin-1-yl group,         or a C₁₋₄-alkyl group substituted by a group R_(b), where R_(b)         is as hereinbefore defined,         Y denotes a nitrogen atom or a group of formula C—R⁵,     -   while R⁵ is defined like R² and in each case one of the two         groups R² and R⁵ must be a hydrogen atom or a C₁₋₃-alkyl group,         R³ denotes a C₃₋₈-alkyl group,         a C₁₋₃-alkyl group substituted by a group R_(c), where     -   R_(c) denotes a C₃₋₇-cycloalkyl group optionally substituted by         one or two C₁₋₃-alkyl groups,     -   a C₅₋₇-cycloalkenyl group optionally substituted by one or two         C₁₋₃-alkyl groups,     -   an aryl group or     -   a furanyl, thienyl, oxazolyl, isoxazolyl, thiazolyl,         isothiazolyl, pyridyl, pyridazinyl, pyrimidyl or pyrazinyl         group, while the above mentioned heterocyclic groups may each be         substituted by one or two C₁₋₃-alkyl groups or by a fluorine,         chlorine, bromine or iodine atom or by a trifluoromethyl, cyano         or C₁₋₃-alkyloxy group,         a C₃₋₈-alkenyl group,         a C₃₋₆-alkenyl group substituted by a fluorine, chlorine or         bromine atom or by a trifluoromethyl group,         a C₃₋₈-alkynyl group,         an aryl group or         an aryl-C₂₋₄-alkenyl group,         and         R⁴ denotes an azetidin-1-yl or pyrrolidin-1-yl group which is         substituted in the 3 position by an amino, C₁₋₃-alkylamino or a         di-(C₁₋₃-alkyl)amino group and may additionally be substituted         by one or two C₁₋₃-alkyl groups,         a piperidin-1-yl or hexahydroazepin-1-yl group which is         substituted in the 3 position or in the 4 position by an amino,         C₁₋₃-alkylamino or a di-(C₁₋₃-alkyl)amino group and may         additionally be substituted by one or two C₁₋₃-alkyl groups,         a 3-amino-piperidin-1-yl group wherein the piperidin-1-yl moiety         is additionally substituted by an aminocarbonyl,         C₁₋₂-alkyl-aminocarbonyl, di-(C₁₋₂-alkyl)aminocarbonyl,         pyrrolidin-1-yl-carbonyl, (2-cyano-pyrrolidin-1-yl-)carbonyl,         thiazolidin-3-yl-carbonyl, (4-cyano-thiazolidin-3-yl)carbonyl,         piperidin-1-ylcarbonyl or morpholin-4-ylcarbonyl group,         a 3-amino-piperidin-1-yl group wherein the piperidin-1-yl moiety         in the 4 position or in the 5 position is additionally         substituted by a hydroxy or methoxy group,         a 3-amino-piperidin-1-yl group wherein the methylene group in         the 2 position or in the 6 position is replaced by a carbonyl         group,         a piperidin-1-yl or hexahydroazepin-1-yl group substituted in         the 3 position by an amino, C₁₋₃-alkylamino or         di-(C₁₋₃-alkyl)-amino-group, wherein in each case two hydrogen         atoms on the carbon skeleton of the piperidin-1-yl or         hexahydroazepin-1-yl-group are replaced by a straight-chain         alkylene bridge, this bridge containing 2 to 5 carbon atoms if         the two hydrogen atoms are located on the same carbon atom, or 1         to 4 carbon atoms, if the hydrogen atoms are located on adjacent         carbon atoms, or 1 to 4 carbon atoms, if the hydrogen atoms are         located on carbon atoms which are separated by one atom, or 1 to         3 carbon atoms if the two hydrogen atoms are located on carbon         atoms separated by two atoms,         an azetidin-1-yl, pyrrolidin-1-yl, piperidin-1-yl or         hexahydroazepin-1-yl group which is substituted by an         amino-C₁₋₃-alkyl, C₁₋₃-alkylamino-C₁₋₃-alkyl or a         di-(C₁₋₃-alkyl)-amino-C₁₋₃-alkyl group,         a piperazin-1-yl or [1,4]diazepan-1-yl group optionally         substituted at the carbon skeleton by one or two C₁₋₃-alkyl         groups,         a 3-imino-piperazin-1-yl, 3-imino-[1,4]diazepan-1-yl or         5-imino-[1,4]diazepan-1-yl group optionally substituted at the         carbon skeleton by one or two C₁₋₃-alkyl groups,         a [1,4]diazepan-1-yl group optionally substituted by one or two         C₁₋₃-alkyl groups, which is substituted in the 6 position by an         amino group,         a C₃₋₇-cycloalkyl group which is substituted by an amino,         C₁₋₃-alkylamino or di-(C₁₋₃-alkyl)-amino group,         a C₃₋₇-cycloalkyl group which is substituted by an         amino-C₁₋₃-alkyl, C₁₋₃-alkylamino-C₁₋₃-alkyl or a         di-(C₁₋₃-alkyl)amino-C₁₋₃-alkyl group,         a C₃₋₇-cycloalkyl-C₁₋₂-alkyl group wherein the cycloalkyl moiety         is substituted by an amino, C₁₋₃-alkylamino or         di-(C₁₋₃-alkyl)-amino group,         a C₃₋₇-cycloalkyl-C₁₋₂-alkyl group wherein the cycloalkyl moiety         is substituted by an amino-C₁₋₃-alkyl,         C₁₋₃-alkylamino-C₁₋₃-alkyl or a di-(C₁₋₃-alkyl)amino-C₁₋₃-alkyl         group,         a C₃₋₇-cycloalkylamino group wherein the cycloalkyl moiety is         substituted by an amino, C₁₋₃-alkylamino or         di-(C₁₋₃-alkyl)-amino group, while the two nitrogen atoms at the         cycloalkyl moiety are separated from one another by at least two         carbon atoms,         an N—(C₃₋₇-cycloalkyl)-N—(C₁₋₃-alkyl)-amino group wherein the         cycloalkyl moiety is substituted by an amino, C₁₋₃-alkylamino or         di-(C₁₋₃-alkyl)-amino group, while the two nitrogen atoms at the         cycloalkyl moiety are separated from one another by at least two         carbon atoms,         a C₃₋₇-cycloalkylamino group wherein the cycloalkyl moiety is         substituted by an amino-C₁₋₃-alkyl, C₁₋₃-alkylamino-C₁₋₃-alkyl         or a di-(C₁₋₃-alkyl)amino-C₁₋₃-alkyl group,         an N—(C₃₋₇-cycloalkyl)-N—(C₁₋₃-alkyl)-amino group wherein the         cycloalkyl moiety is substituted by an amino-C₁₋₃-alkyl,         C₁₋₃-alkylamino-C₁₋₃-alkyl or a di-(C₁₋₃-alkyl)amino-C₁₋₃-alkyl         group,         a C₃₋₇-cycloalkyl-C₁₋₂-alkyl-amino group wherein the cycloalkyl         moiety is substituted by an amino, C₁₋₃-alkylamino or         di-(C₁₋₃-alkyl)-amino group,         an N—(C₃₋₇-cycloalkyl-C₁₋₂-alkyl)-N—(C₁₋₂-alkyl)-amino group         wherein the cycloalkyl moiety is substituted by an amino,         C₁₋₃-alkylamino or di-(C₁₋₃-alkyl)-amino group,         a C₃₋₇-cycloalkyl-C₁₋₂-alkyl-amino group wherein the cycloalkyl         moiety is substituted by an amino-C₁₋₃-alkyl,         C₁₋₃-alkylamino-C₁₋₃-alkyl or a di-(C₁₋₃-alkyl)amino-C₁₋₃-alkyl         group,         an N—(C₃₋₇-cycloalkyl-C₁₋₂-alkyl)-N—(C₁₋₂-alkyl)-amino group         wherein the cycloalkyl moiety is substituted by an         amino-C₁₋₃-alkyl, C₁₋₃-alkylamino-C₁₋₃-alkyl or a         di-(C₁₋₃-alkyl)amino-C₁₋₃-alkyl group,         a R¹⁹—C₂₋₄-alkylamino group wherein R¹⁹ is separated from the         nitrogen atom of the C₂₋₄-alkylamino moiety by at least two         carbon atoms and     -   R¹⁹ denotes an amino, C₁₋₃-alkylamino or di-(C₁₋₃-alkyl)-amino         group,         an R¹⁹—C₂₋₄-alkylamino group wherein the nitrogen atom of the         C₂₋₄-alkylamino moiety is substituted by a C₁₋₃-alkyl group and         R¹⁹ is separated from the nitrogen atom of the C₂₋₄-alkylamino         moiety by at least two carbon atoms, while R¹⁹ is as         hereinbefore defined,         an amino group substituted by the group R²⁰ wherein     -   R²⁰ denotes an azetidin-3-yl, azetidin-2-ylmethyl,         azetidin-3-ylmethyl, pyrrolidin-3-yl, pyrrolidin-2-ylmethyl,         pyrrolidin-3-ylmethyl, piperidin-3-yl, piperidin-4-yl,         piperidin-2-ylmethyl, piperidin-3-ylmethyl or         piperidin-4-ylmethyl group, while the groups mentioned for R²⁰         may each be substituted by one or two C₁₋₃-alkyl groups,         an amino group substituted by the group R²⁰ and a C₁₋₃-alkyl         group wherein R²⁰ is as hereinbefore defined, while the groups         mentioned for R²⁰ may each be substituted by one or two         C₁₋₃-alkyl groups,         an R¹⁹—C₃₋₄-alkyl group wherein the C₃₋₄-alkyl moiety is         straight-chained and may additionally be substituted by one or         two C₁₋₃-alkyl groups, while R¹⁹ is as hereinbefore defined,         a 3-amino-2-oxo-piperidin-5-yl or         3-amino-2-oxo-1-methyl-piperidin-5-yl group,         a pyrrolidin-3-yl, piperidin-3-yl, piperidin-4-yl,         hexahydroazepin-3-yl or hexahydroazepin-4-yl group which is         substituted in the 1 position by an amino, C₁₋₃-alkylamino or         di-(C₁₋₃-alkyl)amino group,         or an azetidin-2-yl-C₁₋₂-alkyl, azetidin-3-yl-C₁₋₂-alkyl,         pyrrolidin-2-yl-C₁₋₂-alkyl, pyrrolidin-3-yl,         pyrrolidin-3-yl-C₁₋₂-alkyl, piperidin-2-yl-C₁₋₂-alkyl,         piperidin-3-yl, piperidin-3-yl-C₁₋₂-alkyl, piperidin-4-yl or         piperidin-4-yl-C₁₋₂-alkyl group, while the above mentioned         groups may each be substituted by one or two C₁₋₃-alkyl groups,         while by the aryl groups mentioned in the definition of the         above groups are meant phenyl or naphthyl groups which may be         mono- or disubstituted by R_(h), while the substituents may be         identical or different and R_(h) denotes a fluorine, chlorine,         bromine or iodine atom, a trifluoromethyl, cyano, nitro, amino,         aminocarbonyl, aminosulphonyl, methylsulphonyl, acetylamino,         methylsulphonylamino, C₁₋₃-alkyl, cyclopropyl, ethenyl, ethynyl,         hydroxy, C₁₋₃-alkyloxy, difluoromethoxy or trifluoromethoxy         group,         by the heteroaryl groups mentioned in the definition of the         above groups are meant a pyrrolyl, furanyl, thienyl, pyridyl,         indolyl, benzofuranyl, benzothiophenyl, quinolinyl or         isoquinolinyl group,         or a pyrrolyl, furanyl, thienyl or pyridyl group, wherein one or         two methyne groups are replaced by nitrogen atoms,         or an indolyl, benzofuranyl, benzothiophenyl, quinolinyl or         isoquinolinyl group, wherein one to three methyne groups are         replaced by nitrogen atoms,     -   and the above mentioned heteroaryl groups may be mono- or         disubstituted by R_(h), while the substituents may be identical         or different and R_(h) is as hereinbefore defined,         while, unless otherwise stated, the above mentioned alkyl,         alkenyl and alkynyl groups may be straight-chain or branched,         and the hydrogen atoms of the methyl or ethyl groups contained         in the definitions may be wholly or partly replaced by fluorine         atoms,         the tautomers, enantiomers, diastereomers, the mixtures thereof,         the prodrugs thereof and the salts thereof.

Compounds of the above general formula I which contain one or more groups that can be cleaved in vivo are so-called prodrugs.

The carboxy groups mentioned in the definition of the above mentioned groups may be replaced by a group which can be converted into a carboxy group in vivo or by a group which is negatively charged under physiological conditions,

and furthermore the amino and imino groups mentioned in the definition of the above mentioned groups may be substituted by a group which can be cleaved in vivo. Such groups are described for example in WO 98/46576 and by N. M. Nielsen et al. in International Journal of Pharmaceutics 39, 75-85 (1987).

By a group which can be converted in vivo into a carboxy group is meant, for example, a hydroxymethyl group, a carboxy group esterified with an alcohol wherein the alcohol moiety is preferably a C₁₋₆-alkanol, a phenyl-C₁₋₃-alkanol, a C₃₋₉-cycloalkanol, while a C₅₋₈-cycloalkanol may additionally be substituted by one or two C₁₋₃-alkyl groups, a C₅₋₈-cycloalkanol wherein a methylene group in the 3 or 4 position is replaced by an oxygen atom or by an imino group optionally substituted by a C₁₋₃-alkyl, phenyl-C₁₋₃-alkyl, phenyl-C₁₋₃-alkyloxycarbonyl or C₂₋₆-alkanoyl group and the cycloalkanol moiety may additionally be substituted by one or two C₁₋₃-alkyl groups, a C₄₋₇-cycloalkenol, a C₃₋₅-alkenol, a phenyl-C₃₋₅-alkenol, a C₃₋₅-alkynol or phenyl-C₃₋₅-alkynol with the proviso that no bonds to the oxygen atom start from a carbon atom which carries a double or triple bond, a C₃₋₈-cycloalkyl-C₁₋₃-alkanol, a bicycloalkanol with a total of 8 to 10 carbon atoms which may additionally be substituted in the bicycloalkyl moiety by one or two C₁₋₃-alkyl groups, a 1,3-dihydro-3-oxo-1-isobenzofuranol or an alcohol of formula R_(p)—CO—O—(R_(q)CR_(r))—OH, wherein

-   -   R_(p) denotes a C₁₋₈-alkyl, C₅₋₇-cycloalkyl, C₁₋₈-alkyloxy,         C₅₋₇-cycloalkyloxy, phenyl or phenyl-C₁₋₃-alkyl group,     -   R_(q) denotes a hydrogen atom, a C₁₋₃-alkyl, C₅₋₇-cycloalkyl or         phenyl group and     -   R_(r) denotes a hydrogen atom or a C₁₋₃-alkyl group,         by a group which is negatively charged under physiological         conditions is meant, for example, a tetrazol-5-yl,         phenylcarbonylaminocarbonyl,         trifluoromethylcarbonylaminocarbonyl, C₁₋₆-alkylsulphonylamino,         phenylsulphonylamino, benzylsulphonylamino,         trifluoromethyl-sulphonylamino,         C₁₋₆-alkylsulphonylaminocarbonyl, phenylsulphonylaminocarbonyl,         benzylsulphonylaminocarbonyl or         perfluoro-C₁₋₆-alkylsulphonylaminocarbonyl group         and by a group which can be cleaved in vivo from an imino or         amino group is meant, for example, a hydroxy group, an acyl         group such as a phenylcarbonyl group optionally mono- or         disubstituted by fluorine, chlorine, bromine or iodine atoms, by         C₁₋₃-alkyl or C₁₋₃-alkyloxy groups, while the substituents may         be identical or different, a pyridinoyl group or a         C₁₋₁₆-alkanoyl group such as the formyl, acetyl, propionyl,         butanoyl, pentanoyl or hexanoyl group, a         3,3,3-trichloropropionyl or allyloxycarbonyl group, a         C₁₋₁₆-alkyloxycarbonyl or C₁₋₆-alkylcarbonyloxy group, wherein         hydrogen atoms may be wholly or partially replaced by fluorine         or chlorine atoms such as the methoxycarbonyl, ethoxycarbonyl,         propoxycarbonyl, isopropoxycarbonyl, butoxycarbonyl,         tert.butoxycarbonyl, pentoxycarbonyl, hexoxycarbonyl,         octyloxycarbonyl, nonyloxycarbonyl, decyloxycarbonyl,         undecyloxycarbonyl, dodecyloxycarbonyl, hexadecyloxycarbonyl,         methylcarbonyloxy, ethylcarbonyloxy,         2,2,2-trichloroethylcarbonyloxy, propylcarbonyloxy,         isopropylcarbonyloxy, butylcarbonyloxy, tert.butylcarbonyloxy,         pentylcarbonyloxy, hexylcarbonyloxy, octylcarbonyloxy,         nonylcarbonyloxy, decylcarbonyloxy, undecylcarbonyloxy,         dodecylcarbonyloxy or hexadecylcarbonyloxy group, a         phenyl-C₁₋₆-alkyloxycarbonyl group such as the         benzyloxycarbonyl, phenylethoxycarbonyl or phenylpropoxycarbonyl         group, a 3-amino-propionyl group wherein the amino group may be         mono- or disubstituted by C₁₋₆-alkyl or C₃₋₇-cycloalkyl groups         and the substituents may be identical or different, a         C₁₋₃-alkylsulphonyl-C₂₋₄-alkyloxycarbonyl,         C₁₋₃-alkyloxy-C₂₋₄-alkyloxy-C₂₋₄-alkyloxycarbonyl,         R_(p)—CO—O—(R_(q)CR_(r))—O—CO,         C₁₋₆-alkyl-CO—NH—(R_(s)CR_(t))—O—CO or         C₁₋₆-alkyl-CO—O—(R_(s)CR_(t))—(R_(s)CR_(t))—O—CO group, wherein         R_(p) to R_(r) are as hereinbefore defined,     -   R_(s), and R_(t), which may be identical or different, denote         hydrogen atoms or C₁₋₃-alkyl groups.

Moreover, the saturated alkyl and alkyloxy moieties which contain more than 2 carbon atoms mentioned in the foregoing definitions and those that follow, unless otherwise stated, also include the branched isomers thereof such as, for example, the isopropyl, tert.butyl, isobutyl group, etc.

Preferred compounds of the above general formula I are those wherein

R¹ denotes a methyl group substituted by a group R_(a), where

-   -   R_(a) denotes a 3,4-dihydro-quinolinyl group,     -   a 3,4-dihydro-isoquinolinyl group,     -   a 1,4-dihydro-quinazolinyl or 4-oxo-1,4-dihydro-quinazolinyl         group,     -   a 3,4-dihydro-quinazolinyl or 4-oxo-3,4-dihydro-quinazolinyl         group,     -   a 1H-benzo[d][1,2]oxazinyl or 1-oxo-1H-benzo[d][1,2]oxazinyl         group,     -   a 4H-benzo[e][1,3]oxazinyl or 4-oxo-4H-benzo[e][1,3]oxazinyl         group,     -   a 4H-benzo[d][1,3]oxazinyl or 4-oxo-4H-benzo[d][1,3]oxazinyl         group,     -   a 2H-benzo[1,4]oxazinyl or 2-oxo-2H-benzo[1,4]oxazinyl group,     -   a 4H-benzo[e][1,3]thiazinyl or 4-oxo-4H-benzo[e][1,3]thiazinyl         group,     -   a 4H-benzo[d][1,3]thiazinyl or 2H-benzo[1,4]thiazinyl group,     -   a 2-oxo-2H-benzo[e][1,3]oxazinyl or         2,2-dioxo-1H-benzo[c][1,2]thiazinyl group,     -   a 2,3-dihydro-1H-benzo[e][1,4]diazepinyl or         2-oxo-2,3-dihydro-1H-benzo[e][1,4]diazepinyl group,     -   a 4,5-dihydro-3H-benzo[b][1,4]diazepinyl or         4-oxo-4,5-dihydro-3H-benzo[b][1,4]diazepinyl group,     -   a 5-oxo-4,5-dihydro-3H-benzo[e][1,4]diazepinyl group,     -   a 2,3-dihydro-benzo[f][1,4]oxazepinyl or         2,3-dihydro-benzo[b][1,4]oxazepinyl group,     -   a 2,3-dihydro-benzo[f][1,4]thiazepinyl or         2,3-dihydro-benzo[b][1,4]thiazepinyl group,     -   a 5-oxo-4,5-dihydro-benzo[f][1,3,4]oxadiazepinyl group,     -   a 11H-dibenzo[b,e]azepinyl or 11-oxo-11H-dibenzo[b,e]azepinyl         group,     -   a 11H-benzo[e]pyrido[3,2-b]azepinyl or a         5H-1,9,10-triaza-dibenzo[a,d]cycloheptenyl group,     -   a 5H-dibenzo[b,e][1,4]diazepinyl or dibenzo[b,f][1,4]oxazepinyl         group,     -   a dibenzo[b,f][1,4]thiazepinyl,         5-oxo-dibenzo[b,f][1,4]thiazepinyl or         5,5-dioxo-dibenzo[b,f][1,4]thiazepinyl group,     -   a 5H-dibenzo[a,d]cycloheptenyl or 5H-dibenzo[b,f]azepinyl group,     -   a phenanthridinyl, benzo[c][1,5]naphthyridinyl,         benzo[h][1,6]naphthyridinyl, benzo[c][1,8]naphthyridinyl,         benzo[f][1,7]naphthyridinyl or 1,5,9-triaza-phenanthrenyl group,     -   a 1,2,3,4-tetrahydro-phenanthridinyl,         1,2,3,4,4a,10b-hexahydro-phenanthridinyl,         2,3-dihydro-1H-4-aza-cyclopenta[a]naphthyl or         8,9,10,11-tetrahydro-7H-6-aza-cyclohepta[a]naphthyl group,     -   a 2,3-dihydro-1H-4-oxa-10-aza-phenanthrenyl or         1-oxo-2,3-dihydro-1H-4-oxa-10-aza-phenanthrenyl group,     -   a phenanthrenyl, benzo[h]quinolinyl, benzo[f]quinolinyl or         benzo[f]quinoxalinyl group,     -   a 5H-benzo[e]pyrrolo[1,2-a][1,4]diazepinyl,         thieno[3,2-b][1,4]benzoxazepinyl, 5H-dibenzo[d,f][1,3]diazepinyl         or 5-oxa-7-aza-dibenzo[a,c]cycloheptenyl group,     -   a naphtho[1,2-d]oxazolyl, naphtho[2,1-d]oxazolyl,         naphtho[1,2-d]thiazolyl, naphtho[2,1-d]thiazolyl,         naphtho[1,2-d]imidazolyl, naphtho[1,2-b]furanyl or         naphtho[2,1-b]furanyl group,     -   or a furo[3,2-c]isoquinolinyl, pyrazolo[1,5-c]quinazolinyl or         1H-perimidinyl group,     -   while the benzo groups of the above mentioned radicals R_(a) are         substituted by the groups R¹⁰ to R¹³ and the alkylene units of         the above mentioned groups R_(a) may be substituted by one or         two fluorine atoms or one or two C₁₋₃-alkyl or         C₁₋₃-alkyloxy-carbonyl groups and the imino groups of the above         mentioned radicals R_(a) may be substituted by a C₁₋₃-alkyl         group and         -   R¹⁰ denotes a hydrogen atom,         -   a fluorine, chlorine, bromine or iodine atom,         -   a C₁₋₃-alkyl or cyclopropyl group,         -   a hydroxy, C₁₋₃-alkyloxy or cyclopropyloxy group,         -   a nitro, amino, C₁₋₃-alkylamino or di-(C₁₋₃-alkyl)amino             group,         -   a C₁₋₃-alkyl-carbonylamino or C₁₋₃-alkyl-sulphonylamino             group,         -   a cyano, carboxy, C₁₋₃-alkyloxy-carbonyl, aminocarbonyl,             C₁₋₃-alkyl-aminocarbonyl or di-(C₁₋₃-alkyl)-aminocarbonyl             group,         -   a mercapto, C₁₋₃-alkylsulphanyl, C₁₋₃-alkysulphinyl,             C₁₋₃-alkylsulphonyl or aminosulphonyl group or         -   a difluoromethyl, trifluoromethyl, difluoromethoxy or             trifluoromethoxy group and         -   R¹¹, R¹² and R¹³, which may be identical or different, in             each case represent a hydrogen atom, a fluorine, chlorine or             bromine atom, a methyl, trifluoromethyl or methoxy group,             R² denotes a hydrogen atom or             a C₁₋₃-alkyl, cyclopropyl, trifluoromethyl, cyanomethyl or             2-cyano-ethyl group,             Y denotes a nitrogen atom or a group of formula C—R⁵,     -   while R⁵ denotes a hydrogen atom or a C₁₋₃-alkyl group,         R³ denotes a 2-buten-1-yl or 3-methyl-2-buten-1-yl group,         a 1-buten-1-yl group,         a 2-butyn-1-yl group or         a 1-cyclopenten-1-ylmethyl group         and         R⁴ denotes a (3-amino-piperidin-1-yl) group,         while, unless otherwise stated, the above mentioned alkyl groups         may be straight-chain or branched,         the tautomers, enantiomers, diastereomers, the mixtures thereof         and the salts thereof.

Particularly preferred are those compounds of the above general formula I wherein

R¹ denotes a methyl group substituted by a group R_(a), where

-   -   R_(a) denotes a 3,4-dihydro-quinolin-2-yl group,     -   a 3,4-dihydro-isoquinolin-1-yl group,     -   a 1,4-dihydro-quinazolin-2-yl or         4-oxo-1,4-dihydro-quinazolin-2-yl group,     -   a 3,4-dihydro-quinazolin-2-yl or         4-oxo-3,4-dihydro-quinazolin-2-yl group,     -   a 1H-benzo[d][1,2]oxazin-4-yl or         1-oxo-1H-benzo[d][1,2]oxazin-4-yl group,     -   a 4H-benzo[e][1,3]oxazin-2-yl or         4-oxo-4H-benzo[e][1,3]oxazin-2-yl group,     -   a 4H-benzo[d][1,3]oxazin-2-yl or         4-oxo-4H-benzo[d][1,3]oxazin-2-yl group,     -   a 2H-benzo[1,4]oxazin-3-yl or 2-oxo-2H-benzo[1,4]oxazin-3-yl         group,     -   a 4H-benzo[e][1,3]thiazin-2-yl or         4-oxo-4H-benzo[e][1,3]thiazin-2-yl group,     -   a 4H-benzo[d][1,3]thiazin-2-yl or 2H-benzo[1,4]thiazin-3-yl         group,     -   a 2-oxo-2H-benzo[e][1,3]oxazin-4-yl or         2,2-dioxo-1H-benzo[c][1,2]thiazin-4-yl group,     -   a 2,3-dihydro-1H-benzo[e][1,4]diazepin-5-yl or         2-oxo-2,3-dihydro-1H-benzo[e][1,4]diazepin-5-yl group,     -   a 4,5-dihydro-3H-benzo[b][1,4]diazepin-2-yl or         4-oxo-4,5-dihydro-3H-benzo[b][1,4]diazepin-2-yl group,     -   a 5-oxo-4,5-dihydro-3H-benzo[e][1,4]diazepin-2-yl group,     -   a 2,3-dihydro-benzo[f][1,4]oxazepin-5-yl or         2,3-dihydro-benzo[b][1,4]oxazepin-4-yl group,     -   a 2,3-dihydro-benzo[f][1,4]thiazepin-5-yl or         2,3-dihydro-benzo[b][1,4]thiazepin-4-yl group,     -   a 5-oxo-4,5-dihydro-benzo[f][1,3,4]oxadiazepin-2-yl group,     -   a 11H-dibenzo[b,e]azepin-6-yl or         11-oxo-11H-dibenzo[b,e]azepin-6-yl group,     -   a 11H-benzo[e]pyrido[3,2-b]azepin-6-yl or a         5H-1,9,10-triaza-dibenzo[a,d]-cyclohepten-11-yl group,     -   a 5H-dibenzo[b,e][1,4]diazepin-11-yl or         dibenzo[b,f][1,4]oxazepin-11-yl group,     -   a dibenzo[b,f][1,4]thiazepin-11-yl,         5-oxo-dibenzo[b,f][1,4]thiazepin-11-yl or         5,5-dioxo-dibenzo[b,f][1,4]thiazepin-11-yl group,     -   a 5H-dibenzo[a,d]cyclohepten-10-yl or         5H-dibenzo[b,f]azepin-10-yl group,     -   a phenanthridin-6-yl, benzo[c][1,5]naphthyridin-6-yl,         benzo[h][1,6]naphthyridin-5-yl, benzo[c][1,8]naphthyridin-6-yl,         benzo[f][1,7]naphthyridin-5-yl or 1,5,9-triaza-phenanthren-10-yl         group,     -   a 1,2,3,4-tetrahydro-phenanthridin-6-yl,         1,2,3,4,4a,10b-hexahydro-phenanthridin-6-yl,         2,3-dihydro-1H-4-aza-cyclopenta[a]naphth-5-yl or         8,9,10,11-tetrahydro-7H-6-aza-cyclohepta[a]naphth-5-yl group,     -   a 2,3-dihydro-1H-4-oxa-10-aza-phenanthren-9-yl or         1-oxo-2,3-dihydro-1H-4-oxa-10-aza-phenanthren-9-yl group,     -   a phenanthren-9-yl, benzo[h]quinolin-6-yl, benzo[f]quinolin-6-yl         or benzo[f]quinoxalin-6-yl group,     -   a 5H-benzo[e]pyrrolo[1,2-a][1,4]diazepin-11-yl,         thieno[3,2-b][1,4]benzoxazepin-9-yl,         5H-dibenzo[d,f][1,3]diazepin-6-yl or         5-oxa-7-aza-dibenzo[a,c]cyclohepten-6-yl group,     -   a naphtho[1,2-d]oxazol-2-yl, naphtho[2,1-d]oxazol-2-yl,         naphtho[1,2-d]thiazol-2-yl, naphtho[2,1-d]thiazol-2-yl,         naphtho[1,2-d]imidazol-2-yl, naphtho[1,2-b]furan-2-yl or         naphtho[2,1-b]furan-2-yl group,     -   or a furo[3,2-c]isoquinolin-5-yl, pyrazolo[1,5-c]quinazolin-5-yl         or 1H-perimidin-2-yl group,     -   while the benzo groups of the above mentioned radicals R_(a) are         substituted by the groups R¹⁰ to R¹³ and the alkylene units of         the above mentioned groups R_(a) may be substituted by one or         two fluorine atoms or one or two methyl groups and the imino         groups of the above mentioned radicals R_(a) may be substituted         by a methyl group and         -   R¹⁰ denotes a hydrogen atom,         -   a fluorine, chlorine, bromine or iodine atom,         -   a methyl or ethyl group,         -   a hydroxy, methoxy or ethoxy group or         -   a difluoromethyl, trifluoromethyl, difluoromethoxy, or             trifluoromethoxy group and         -   R¹¹, R¹² and R¹³, which may be identical or different, each             denote a hydrogen, fluorine, chlorine or bromine atom or a             methyl, trifluoromethyl or methoxy group,             R² denotes a hydrogen atom or             a methyl, cyanomethyl, trifluoromethyl, ethyl,             2-cyano-ethyl, propyl, cyclopropyl or isopropyl group,             Y denotes a nitrogen atom or a group of formula C—R⁵,     -   while R⁵ denotes a hydrogen atom or a methyl, ethyl, propyl or         isopropyl group,         R³ denotes a 2-buten-1-yl or 3-methyl-2-buten-1-yl group,         a 1-buten-1-yl group,         a 2-butyn-1-yl group or         a 1-cyclopenten-1-ylmethyl group         and         R⁴ denotes a (3-amino-piperidin-1-yl) group,         the tautomers, enantiomers, diastereomers, the mixtures thereof         and the salts thereof.

Most particularly preferred are those compounds of the above general formula I wherein

R¹ denotes a 4-oxo-3,4-dihydro-quinazolin-2-ylmethyl group,

a dibenzo[b,f][1,4]oxazepin-11-ylmethyl group,

a phenanthridin-6-ylmethyl group,

a phenanthren-9-ylmethyl group or

a naphtho[1,2-d]oxazol-2-ylmethyl or naphtho[2,1-d]oxazol-2-ylmethyl group,

R² denotes a hydrogen atom or a methyl group,

Y denotes a nitrogen atom,

R³ denotes a 2-butyn-1-yl group

and

R⁴ denotes a (3-amino-piperidin-1-yl) group,

the tautomers, enantiomers, diastereomers, the mixtures thereof and the salts thereof.

The following compounds of general formula I deserve special mention:

-   (1)     2-(3-amino-piperidin-1-yl)-3-(2-butyn-1-yl)-5-[(dibenzo[b,f][1,4]oxazepin-11-yl)methyl]-3,5-dihydro-imidazo[4,5-d]pyridazin-4-one

-   (2)     2-(3-amino-piperidin-1-yl)-3-(2-butyn-1-yl)-5-[(phenanthridin-6-yl)methyl]-3,5-dihydro-imidazo[4,5-d]pyridazin-4-one

-   (3)     2-(3-amino-piperidin-1-yl)-3-(2-butyn-1-yl)-5-[(phenanthren-9-yl)methyl]-3,5-dihydro-imidazo[4,5-d]pyridazin-4-one

-   (4)     2-((R)-3-amino-piperidin-1-yl)-3-(2-butyn-1-yl)-5-[(phenanthridin-6-yl)methyl]-7-methyl-3,5-dihydro-imidazo[4,5-d]pyridazin-4-one

-   (5)     2-((R)-3-amino-piperidin-1-yl)-3-(2-butyn-1-yl)-5-[(dibenzo[b,f][1,4]oxazepin-11-yl)methyl]-7-methyl-3,5-dihydro-imidazo[4,5-d]pyridazin-4-one

-   (6)     2-((S)-3-amino-piperidin-1-yl)-3-(2-butyn-1-yl)-5-[(dibenzo[b,f][1,4]oxazepin-11-yl)methyl]-3,5-dihydro-imidazo[4,5-d]pyridazin-4-one

-   (7)     2-((R)-3-amino-piperidin-1-yl)-3-(2-butyn-1-yl)-5-[(dibenzo[b,f][1,4]oxazepin-11-yl)methyl]-3,5-dihydro-imidazo[4,5-d]pyridazin-4-one

-   (8)     2-((R)-3-amino-piperidin-1-yl)-3-(2-butyn-1-yl)-5-[(naphtho[2,1-d]oxazol-2-yl)methyl]-3,5-dihydro-imidazo[4,5-d]pyridazin-4-one

-   (9)     2-((R)-3-amino-piperidin-1-yl)-3-(2-butyn-1-yl)-5-[(naphtho[1,2-d]oxazol-2-yl)methyl]-3,5-dihydro-imidazo[4,5-d]pyridazin-4-one

-   (10)     2-((R)-3-amino-piperidin-1-yl)-3-(2-butyn-1-yl)-5-[(4-oxo-3,4-dihydro-quinazolin-2-yl)methyl]-3,5-dihydro-imidazo[4,5-d]pyridazin-4-one

the enantiomers, the mixtures thereof and the salts thereof. According to the invention the compounds of general formula I are obtained by methods known per se, for example by the following methods: a) deprotecting a compound of general formula

wherein R¹, R², Y and R³ are as hereinbefore defined and R⁴″ denotes one of the groups mentioned for R⁴ hereinbefore which contain an imino, amino or alkylamino group, while the imino, amino or alkylamino group is substituted by a protective group.

The liberating of an amino group from a protected precursor is a standard reaction in synthetic organic chemistry. There are many examples of suitable protective groups. A summary of the chemistry of protective groups can be found in Theodora W. Greene and Peter G. M. Wuts, Protective Groups in Organic Synthesis, Second Edition, 1991, published by John Wiley and Sons, and in Philip J. Kocienski, Protecting Groups, published by Georg Thieme, 1994.

The following are examples of protective groups:

the tert.-butyloxycarbonyl group which can be cleaved by treating with an acid such as for example trifluoroacetic acid or hydrochloric acid or by treating with bromotrimethylsilane or iodotrimethylsilane, optionally using a solvent such as methylene chloride, ethyl acetate, dioxane, methanol, isopropanol or diethylether at temperatures between 0° C. and 80° C., the 2,2,2-trichloroethoxycarbonyl group which can be cleaved by treating with metals such as for example zinc or cadmium in a solvent such as acetic acid or a mixture of tetrahydrofuran and a weak aqueous acid at temperatures between 0° C. and the boiling temperature of the solvent used and the carbobenzyloxycarbonyl group which can be cleaved for example by hydrogenolysis in the presence of a noble metal catalyst such as for example palladium-charcoal and a solvent such as for example alcohols, ethyl acetate, dioxane, tetrahydrofuran or mixtures of these solvents at temperatures between 0° C. and the boiling point of the solvent, by treating with boron tribromide in methylene chloride at temperatures between −20° C. and ambient temperature, or by treating with aluminium chloride/anisol at temperatures between 0° C. and ambient temperature.

Moreover, the compounds of general formula I obtained may be resolved into their enantiomers and/or diastereomers, as mentioned hereinbefore. Thus, for example, cis/trans mixtures may be resolved into their cis and trans isomers, and compounds with at least one stereocentre may be separated into their enantiomers.

Thus, for example, the cis/trans mixtures obtained may be resolved by chromatography into the cis and trans isomers thereof, the compounds of general formula I obtained which occur as racemates may be separated by methods known per se (cf. Allinger N. L. and Eliel E. L. in “Topics in Stereochemistry”, Vol. 6, Wiley Interscience, 1971) into their optical antipodes and compounds of general formula I with at least 2 asymmetric carbon atoms may be resolved into their diastereomers on the basis of their physical-chemical differences using methods known per se, e.g. by chromatography and/or fractional crystallisation, and, if these compounds are obtained in racemic form, they may subsequently be resolved into the enantiomers as mentioned above.

The enantiomers are preferably separated by column separation on chiral phases or by recrystallisation from an optically active solvent or by reacting with an optically active substance which forms salts or derivatives such as e.g. esters or amides with the racemic compound, particularly acids and the activated derivatives or alcohols thereof, and separating the diastereomeric mixture of salts or derivatives thus obtained, e.g. on the basis of their differences in solubility, whilst the free antipodes may be released from the pure diastereomeric salts or derivatives by the action of suitable agents. Optically active acids in common use are e.g. the D- and L-forms of tartaric acid or dibenzoyltartaric acid, di-O-p-toluoyltartaric acid, malic acid, mandelic acid, camphorsulphonic acid, glutamic acid, aspartic acid or quinic acid. An optically active alcohol may be for example (+)- or (−)-menthol and an optically active acyl group in amides, for example, may be a (+)- or (−)-menthyloxycarbonyl.

Furthermore, the compounds of formula I obtained may be converted into the salts thereof, particularly for pharmaceutical use into the physiologically acceptable salts with inorganic or organic acids. Acids which may be used for this purpose include for example hydrochloric acid, hydrobromic acid, sulphuric acid, methanesulphonic acid, phosphoric acid, fumaric acid, succinic acid, lactic acid, citric acid, tartaric acid or maleic acid.

Moreover, if the new compounds of formula I thus obtained contain a carboxy group, they may subsequently, if desired, be converted into the salts thereof with inorganic or organic bases, particularly for pharmaceutical use into the physiologically acceptable salts thereof. Suitable bases for this purpose include for example sodium hydroxide, potassium hydroxide, arginine, cyclohexylamine, ethanolamine, diethanolamine and triethanolamine.

The compounds of general formula II used as starting materials are either known from the literature or may be obtained by methods known from the literature (cf. Examples I to XVI).

As already mentioned hereinbefore, the compounds of general formula I according to the invention and the physiologically acceptable salts thereof have valuable pharmacological properties, particularly an inhibiting effect on the enzyme DPP-IV.

The biological properties of the new compounds were investigated as follows:

The ability of the substances and their corresponding salts to inhibit the DPP-IV activity can be demonstrated in a test set-up in which an extract of human colon carcinoma cell line Caco-2 is used as the DPP IV source. The differentiation of the cells in order to induce the DPP-IV expression was carried out as described by Reiher et al. in an article entitled “Increased expression of intestinal cell line Caco-2”, which appeared in Proc. Natl. Acad. Sci. Vol. 90, pages 5757-5761 (1993). The cell extract was obtained from cells solubilised in a buffer (10 mM Tris HCl, 0.15 M NaCl, 0.04 t.i.u. aprotinin, 0.5% Nonidet-P40, pH 8.0) by centrifuging at 35,000 g for 30 minutes at 4° C. (to remove cell debris).

The DPP-IV assay was carried out as follows:

50 μl substrate solution (AFC; AFC is amido-4-trifluoromethylcoumarin), final concentration 100 μM, were placed in black microtitre plates. 20 μl of assay buffer (final concentrations 50 mM Tris HCl pH 7.8, 50 mM NaCl, 1% DMSO) was pipetted in. The reaction was started by adding 30 μl of solubilised Caco-2 protein (final concentration 0.14 μg of protein per well). The test substances to be investigated were typically added prediluted in 20 μl, and the volume of assay buffer was then reduced accordingly. The reaction was carried out at ambient temperature, incubating for 60 minutes. Then the fluorescence was measured in a Victor 1420 Multilabel Counter, the excitation wavelength being 405 nm and the emission wavelength being 535 nm. Blank readings (corresponding to 0% activity) were obtained in mixtures without any Caco-2 protein (volume replaced by assay buffer), control values (corresponding to 100% activity) were obtained in mixtures with no substance added. The potency of the test substances in question, expressed as IC₅₀ values, was calculated from dosage/activity curves consisting of 11 measuring points in each case. The following results were obtained:

Compound DPP IV inhibition (Example No.) IC₅₀ [nM] 1 14 1(1) 17 1(2) 58 1(3) 8 1(4) 9 1(7) 3 1(8) 7 1(9) 3

The compounds prepared according to the invention are well tolerated, as for example when 10 mg/kg of the compound of Example 1 were administered to rats by oral route no changes in the animals' behaviour could be detected.

In view of their ability to inhibit DPP-IV activity, the compounds of general formula I according to the invention and the corresponding pharmaceutically acceptable salts thereof are suitable for treating all those conditions or illnesses which can be influenced by the inhibition of the DPP-IV activity. It is therefore to be expected that the compounds according to the invention will be suitable for the prevention or treatment of diseases or conditions such as type I and type II diabetes mellitus, diabetic complications, metabolic acidosis or ketosis, insulin resistance, dyslipidaemias of various origins, arthritis, atherosclerosis and related diseases, obesity, allograft transplantation and calcitonin-induced osteoporosis. In addition these substances are capable of preventing B-cell degeneration such as e.g. apoptosis or necrosis of pancreatic B-cells. The substances are also suitable for improving or restoring the function of pancreatic cells and also increasing the number and size of pancreatic B-cells. Additionally, and on the basis of the role of the Glucagon-Like Peptides, such as e.g. GLP-1 and GLP-2 and their link with DPP-IV inhibition, it is likely that the compounds according to the invention are suitable for achieving, inter alia, a sedative or anxiety-relieving effect and also of favourably affecting catabolic states after operations or hormonal stress responses or of reducing mortality or morbidity after myocardial infarct. They are also suitable for treating all conditions which are connected with the above mentioned effects and which are mediated by GLP-1 or GLP-2. The compounds according to the invention may also be used as diuretics or antihypertensives and are suitable for preventing and treating acute renal failure. They are also suitable for the prevention and treatment of chronic inflammatory intestinal diseases. It is also expected that DPP-IV inhibitors and hence also the compounds according to the invention may be used to treat infertility or to improve fertility in humans or mammals, particularly when the infertility is connected with insulin resistance or polycystic ovary syndrome. The substances are also suitable for treating deficiencies of growth hormone which are associated with reduced stature.

The compounds according to the invention may also be used in conjunction with other active substances. Therapeutic agents which are suitable for such combinations include, for example, antidiabetics, such as metformin, sulphonylureas (e.g. glibenclamide, tolbutamide, glimepiride), nateglinide, repaglinide, thiazolidinedione (e.g. rosiglitazone, pioglitazone), PPAR-gamma agonists (e.g. GI 262570), alpha-glucosidase inhibitors (e.g. acarbose, voglibose), alpha2 antagonists, insulin and insulin analogues, GLP-1 and GLP-1 analogues (e.g. exendin-4) or amylin. Also, inhibitors of protein tyrosine phosphatase 1, substances which influence deregulated glucose production in the liver, such as e.g. inhibitors of glucose-6-phosphatase, or fructose-1,6-bisphosphatase, glycogen phosphorylase, glucagon receptor antagonists and inhibitors of phosphoenol pyruvate carboxykinase, glycogen synthase kinase or pyruvate dehydrokinase, lipid lowering agents, such as HMG-CoA-reductase inhibitors (e.g. simvastatin, atorvastatin), fibrates (e.g. bezafibrate, fenofibrate), nicotinic acid and its derivatives, cholesterol absorption inhibitors such as for example ezetimibe, bile acid-binding substances such as for example cholestyramine, HDL-raising compounds such as for example inhibitors of CETP or regulators of ABC1 or active substances for the treatment of obesity, such as e.g. sibutramine or tetrahydrolipostatin, or β₃-agonists such as SB-418790 or AD-9677.

It is also possible to combine the compounds with drugs for treating high blood pressure such as e.g. AII antagonists or ACE inhibitors, diuretics, β-blockers, etc., or combinations thereof.

The dosage required to achieve such an effect is expediently, by intravenous route, 1 to 100 mg, preferably 1 to 30 mg, and by oral route 1 to 1000 mg, preferably 1 to 100 mg, in each case 1 to 4 times a day. For this purpose, the compounds of formula I prepared according to the invention, optionally combined with other active substances, may be incorporated together with one or more inert conventional carriers and/or diluents, e.g. with corn starch, lactose, glucose, microcrystalline cellulose, magnesium stearate, polyvinylpyrrolidone, citric acid, tartaric acid, water, water/ethanol, water/glycerol, water/sorbitol, water/polyethylene glycol, propylene glycol, cetylstearyl alcohol, carboxymethylcellulose or fatty substances such as hard fat or suitable mixtures thereof into conventional galenic preparations such as plain or coated tablets, capsules, powders, suspensions or suppositories.

The Examples that follow are intended to illustrate the invention:

Preparation of the starting compounds:

EXAMPLE I 2-[3-(tert.-butyloxycarbonylamino)-piperidin-1-yl]-3-(2-butyn-1-yl)-5-[(dibenzo[b,f][1,4]-oxazepin-11-yl)methyl]-3,5-dihydro-imidazo[4,5-d]pyridazin-4-one

317 mg 11-chloromethyl-dibenzo[b,f][1,4]oxazepin are added to 400 mg 2-[3-(tert.-butyloxycarbonylamino)-piperidin-1-yl]-3-(2-butyn-1-yl)-3,5-dihydro-imidazo[4,5-d]pyridazin-4-one and 276 mg potassium carbonate in 4 ml N,N-dimethylformamide. The reaction mixture is stirred for two hours at 80° C. For working up it is combined with water and the precipitate formed is suction filtered. The crude product is purified by chromatography over a silica gel column with methylene chloride/methanol (100:0 to 70:30) as eluant.

Yield: 120 mg (20% of theory)

Mass spectrum (ESI⁺): m/z=594 [M+H]⁺

The following compounds are obtained analogously to Example I:

-   (1)     2-[3-(tert.-butyloxycarbonylamino)-piperidin-1-yl]-3-(2-butyn-1-yl)-5-[(phenanthridin-6-yl)methyl]-3,5-dihydro-imidazo[4,5-d]pyridazin-4-one -   (2)     2-[3-(tert.-butyloxycarbonylamino)-piperidin-1-yl]-3-(2-butyn-1-yl)-5-[(phenanthren-9-yl)methyl]-3,5-dihydro-imidazo[4,5-d]pyridazin-4-one -   (3)     2-[(R)-3-(tert.-butyloxycarbonylamino)-piperidin-1-yl]-3-(2-butyn-1-yl)-5-[(phenanthridin-6-yl)methyl]-7-methyl-3,5-dihydro-imidazo[4,5-d]pyridazin-4-one

R_(f) value: 0.41 (silica gel, cyclohexane/ethyl acetate=3:7)

Mass spectrum (ESI⁺): m/z=592 [M+H]⁺

-   (4)     2-[(R)-3-(tert.-butyloxycarbonylamino)-piperidin-1-yl]-3-(2-butyn-1-yl)-5-[(dibenzo[b,f][1,4]oxazepin-11-yl)methyl]-7-methyl-3,5-dihydro-imidazo[4,5-d]pyridazin-4-one

R_(f) value: 0.50 (silica gel, cyclohexane/ethyl acetate=2:8)

Mass spectrum (ESI⁺): m/z=608 [M+H]⁺

-   (5)     2-bromo-3-(2-butyn-1-yl)-5-[(dibenzo[b,f][1,4]oxazepin-11-yl)methyl]-3,5-dihydro-imidazo[4,5-d]pyridazin-4-one

Mass spectrum (ESI⁺): m/z=474, 476 [M+H]⁺

-   (6)     2-bromo-3-(2-butyn-1-yl)-5-[(naphtho[2,1-d]oxazol-2-yl)methyl]-3,5-dihydro-imidazo[4,5-d]pyridazin-4-one

R_(f) value: 0.80 (silica gel, methylene chloride/ethanol=9:1)

-   (7)     2-bromo-3-(2-butyn-1-yl)-5-[(naphtho[1,2-d]oxazol-2-yl)methyl]-3,5-dihydro-imidazo[4,5-d]pyridazin-4-one

R_(f) value: 0.50 (silica gel, methylene chloride/methanol=19:1)

-   (8)     2-[(R)-3-(tert.-butyloxycarbonylamino)-piperidin-1-yl]-3-(2-butyn-1-yl)-5-cyanomethyl-3,5-dihydro-imidazo[4,5-d]pyridazin-4-one

R_(f) value: 0.40 (silica gel, petroleum ether/ethyl acetate=1:4)

Mass spectrum (ESI⁺): m/z=426 [M+H]⁺

EXAMPLE II 2-[3-(tert.-butyloxycarbonylamino)-piperidin-1-yl]-3-(2-butyn-1-yl)-3,5-dihydro-imidazo[4,5-d]pyridazin-4-one

2.50 g 3-(tert.-butyloxycarbonylamino)-piperidine are added to 2.65 g 2-bromo-3-(2-butyn-1-yl)-3,5-dihydro-imidazo[4,5-d]pyridazin-4-one and 2.12 g sodium carbonate in 5 ml dimethylsulphoxide. The reaction mixture is stirred overnight at 85° C.

After cooling to ambient temperature it is combined with water and extracted with ethyl acetate. The combined organic phases are dried over magnesium carbonate and evaporated down. The crude product is further reacted without any further purification.

Mass spectrum (ESI⁺): m/z=387 [M+H]⁺

The following compounds are obtained analogously to Example II:

-   (1)     2-[(R)-3-(tert.-butyloxycarbonylamino)-piperidin-1-yl]-3-(2-butyn-1-yl)-7-methyl-3,5-dihydro-imidazo[4,5-d]pyridazin-4-one

R_(f) value: 0.15 (silica gel, cyclohexane/ethyl acetate=3:7)

Mass spectrum (ESI⁺): m/z=401 [M+H]⁺

-   (2)     2-[(S)-3-(tert.-butyloxycarbonylamino)-piperidin-1-yl]-3-(2-butyn-1-yl)-5-[(dibenzo[b,f][1,4]oxazepin-11-yl)methyl]-3,5-dihydro-imidazo[4,5-d]pyridazin-4-one

Mass spectrum (ESI⁺): m/z=594 [M+H]⁺

-   (3)     2-[(R)-3-(tert.-butyloxycarbonylamino)-piperidin-1-yl]-3-(2-butyn-1-yl)-5-[(dibenzo[b,f][1,4]oxazepin-11-yl)methyl]-3,5-dihydro-imidazo[4,5-d]pyridazin-4-one

Mass spectrum (ESI⁺): m/z=594 [M+H]⁺

-   (4)     2-[(R)-3-(tert.-butyloxycarbonylamino)-piperidin-1-yl]-3-(2-butyn-1-yl)-5-[(naphtho[2,1-d]oxazol-2-yl)methyl]-3,5-dihydro-imidazo[4,5-d]pyridazin-4-one

R_(f) value: 0.70 (silica gel, methylene chloride/ethanol=9:1)

-   (5)     2-[(R)-3-(tert.-butyloxycarbonylamino)-piperidin-1-yl]-3-(2-butyn-1-yl)-5-[(naphtho[1,2-d]oxazol-2-yl)methyl]-3,5-dihydro-imidazo[4,5-d]pyridazin-4-one

R_(f) value: 0.65 (silica gel, methylene chloride/methanol=9:1)

Mass spectrum (ESI⁺): m/z=568 [M+H]⁺

-   (6)     2-[(R)-3-(tert.-butyloxycarbonylamino)-piperidin-1-yl]-3-(2-butyn-1-yl)-3,5-dihydro-imidazo[4,5-d]pyridazin-4-one

Mass spectrum (ESI⁺): m/z=387 [M+H]⁺

R_(f) value: 0.50 (silica gel, methylene chloride/ethanol=9:1)

EXAMPLE III 2-bromo-3-(2-butyn-1-yl)-3,5-dihydro-imidazo[4,5-d]pyridazin-4-one

0.63 ml hydrazine hydrate are added dropwise to 3.68 g methyl 2-bromo-3-(2-butyn-1-yl)-5-formyl-3H-imidazole-4-carboxylate in 50 ml of ethanol. The reaction mixture is stirred for one hour at ambient temperature, then 3 ml acetic acid are added and the reaction mixture is refluxed for a further hour. The precipitate formed is suction filtered, washed with ethanol and diethyl ether and dried.

Yield: 2.65 g (77% of theory)

Mass spectrum (ESI⁺): m/z=267, 269 [M+H]⁺

EXAMPLE IV methyl 2-bromo-3-(2-butyn-1-yl)-5-formyl-3H-imidazole-4-carboxylate

45 ml diisobutylaluminum hydride solution (1M in toluene) are added dropwise to 12.45 g dimethyl 2-bromo-3-(2-butyn-1-yl)-1H-imidazole-4,5-dicarboxylate in 150 ml of tetrahydrofuran under an argon atmosphere at −65° C. The reaction mixture is stirred for two hours at −65° C., then another 9 ml diisobutylaluminum hydride solution are added. After another hour the reaction mixture is quenched at −65° C. with a mixture of 1 M hydrochloric acid and tetrahydrofuran (1:1) and stirred for ten minutes. Then the cooling bath is removed, the reaction mixture is diluted with water and extracted with ethyl acetate. The combined organic phases are dried over magnesium sulphate and evaporated down. The crude product is purified by chromatography over a silica gel column with cyclohexane/ethyl acetate (2:1 to 1:1).

Yield: 9.58 g (85% of theory)

Mass spectrum (ESI⁺): m/z=285, 287 [M+H]⁺

The following compounds are obtained analogously to Example IV:

-   (1) methyl     2-bromo-3-(3-methyl-2-buten-1-yl)-5-formyl-3H-imidazole-4-carboxylate

Mass spectrum (ESI⁺): m/z=301, 303 [M+H]⁺

EXAMPLE V dimethyl 2-bromo-3-(2-butyn-1-yl)-1H-imidazole-4,5-dicarboxylate

4.53 ml of 1-bromo-2-butyne are added to 13.20 g dimethyl 2-bromo-1H-imidazole-4,5-dicarboxylate and 8.57 g potassium carbonate in 70 ml N,N-dimethylformamide and the reaction mixture is stirred overnight at ambient temperature.

For working up it is combined with water and extracted with ethyl acetate. The combined organic phases are dried over magnesium sulphate and evaporated down.

Yield: 14.58 g (92% of theory)

Mass spectrum (ESI⁺): m/z=315, 317 [M+H]⁺

The following compounds are obtained analogously to Example V:

-   (1) dimethyl     2-bromo-3-(3-methyl-2-buten-1-yl)-1H-imidazole-4,5-dicarboxylate

Mass spectrum (ESI⁺): m/z=331, 333 [M+H]⁺

EXAMPLE VI Dimethyl 2-bromo-1H-imidazole-4,5-dicarboxylate

6.11 ml bromine are added to 19.80 g dimethyl 1H-imidazole-4,5-dicarboxylate and 14.92 g potassium carbonate in 600 ml methylene chloride. The reaction mixture is stirred for one hour at ambient temperature, then a mixture of saturated sodium sulphite solution and saturated sodium chloride solution (1:1) is added. The organic phase is largely separated off and the aqueous phase is extracted with ethyl acetate several times. The combined organic phases are dried over magnesium sulphate and evaporated down, leaving about 7.40 g crude product. The aqueous phase is combined with ethyl acetate and extracted overnight in an extraction apparatus. The ethyl acetate extract is evaporated down and the flask residue is combined with the crude product already obtained.

Yield: 13.10 g (46% of theory)

Mass spectrum (ESI⁺): m/z=263, 265 [M+H]⁺

EXAMPLE VII 2-Bromo-3-(2-butyn-1-yl)-7-methyl-3,5-dihydro-imidazo[4,5-d]pyridazin-4-one

0.50 ml of 1-bromo-2-butyne are added to 1.30 g 2-bromo-7-methyl-3,5-dihydro-imidazo[4,5-d]pyridazin-4-one and 0.99 ml Hünig base in 30 ml of N,N-dimethylformamide. The reaction mixture is stirred for three hours at ambient temperature. Then the solvent is distilled off in vacuo using the rotary evaporator. The flask residue is stirred with 40 ml of water and 0.5 ml concentrated aqueous ammonia solution, suction filtered and washed with ethanol as well as diethyl ether.

Yield: 1.30 g (82% of theory)

R_(f) value: 0.60 (silica gel, cyclohexane/ethyl acetate=3:7)

Mass spectrum (ESI⁺): m/z=281, 283 [M+H]⁺

EXAMPLE VIII 2-bromo-7-methyl-3,5-dihydro-imidazo[4,5-d]pyridazin-4-one

5.20 ml of a 1.8 M solution of bromine in acetonitrile are slowly added dropwise to 1.40 g of 7-methyl-3,5-dihydro-imidazo[4,5-d]pyridazin-4-one and 1.30 g potassium carbonate in 40 ml acetonitrile. Then the reaction mixture is heated to 70° C., whereupon the mixture is rapidly decolourised. More bromine solution and potassium carbonate are added batchwise until the reaction has ended, according to HPLC-MS. For working up the reaction mixture is evaporated down, stirred with 100 ml of water and suction filtered. The filtrate is acidified with 1 M hydrochloric acid and extracted with ethyl acetate. The combined extracts are dried over sodium sulphate and evaporated down.

Yield: 1.30 g (61% of theory)

R_(f) value: 0.37 (silica gel, methylene chloride/methanol=9:1)

Mass spectrum (ESI⁺): m/z=229, 231 [M+H]⁺

EXAMPLE IX 7-methyl-3,5-dihydro-imidazo[4,5-d]pyridazin-4-one

A solution of 4.00 g sodium nitrite in 15 ml of water is added dropwise at 50° C. to 2.20 g of 4-amino-7-methyl-3H-imidazo[4,5-d]pyridazine in a mixture of 30 ml acetic acid, 5 ml of water and 0.5 ml concentrated sulphuric acid. The reaction mixture is stirred for a further two hours at 50° C. and then heated to 90° C. for one hour. After cooling to ambient temperature the reaction mixture is diluted with 30 ml of water. The precipitate formed is suction filtered, washed with water, ethanol and diethyl ether and dried.

Yield: 1.00 g (45% of theory)

Mass spectrum (ESI⁺): m/z=151 [M+H]⁺

EXAMPLE X 4-amino-7-methyl-3H-imidazo[4,5-d]pyridazine

A mixture of 2.00 g 5-acetyl-3H-imidazole-4-carbonitrile and 4.00 ml hydrazine hydrate in 50 ml of ethanol is heated to 100° C., until the reaction is complete according to HPLC-MS. After cooling to ambient temperature the reaction mixture is evaporated down, stirred with 20 ml of cold ethanol and suction filtered. The filter cake is washed with diethyl ether and dried.

Yield: 2.10 g (95% of theory)

Mass spectrum (ESI⁺): m/z=150 [M+H]⁺

EXAMPLE XI 5-acetyl-3H-imidazole-4-carbonitrile

57 ml of a 3 M solution of methylmagnesium bromide in diethyl ether are added to 7.00 g of 4,5-dicyano-imidazole in 80 ml of tetrahydrofuran under an argon atmosphere, while the temperature is maintained between 5° C. and 15° C.

After two hours the reaction is complete according to thin layer chromatography and the reaction mixture is diluted with 400 ml of ethyl acetate. Then 400 ml saturated ammonium chloride solution are slowly added. After ten minutes the mixture is acidified with semiconcentrated sulphuric acid and stirred for another twenty minutes before the organic phase is separated off. The aqueous phase is extracted with ethyl acetate and the combined organic phases are dried over sodium sulphate and evaporated down. The flask residue is stirred with ethyl acetate, suction filtered and washed with ethyl acetate and diethyl ether.

Yield: 3.30 g (43% of theory)

Mass spectrum (ESI⁺): m/z=136 [M+H]⁺

EXAMPLE XII 2-chloromethyl-naphtho[2,1-d]oxazole

Prepared by reacting 2.93 g of 2-amino-1-naphthol with 3.54 g of 2-chloro-1,1,1-triethoxy-ethane in 25 ml of ethanol at 60° C.

Yield: 1.90 g (58% of theory)

R_(f) value: 0.55 (silica gel, petroleum ether/ethyl acetate=9:1)

Mass spectrum (ESI⁺): m/z=218, 220 [M+H]⁺

The following compounds are obtained analogously to Example XII:

-   (1) 2-chloromethyl-naphtho[1,2-d]oxazole

R_(f) value: 0.90 (silica gel, methylene chloride/methanol=19:1)

Mass spectrum (ESI⁺): m/z=218, 220 [M+H]⁺

EXAMPLE XIII 2-bromo-3-(3-methyl-2-buten-1-yl)-3,5-dihydro-imidazo[4,5-c]pyridin-4-one

1.55 g Burgess reagent (methoxycarbonylsulphamoyl-triethylammonium-N-betaine) are added to 1.60 g of 2-bromo-7-hydroxy-3-(3-methyl-2-buten-1-yl)-3,5,6,7-tetrahydro-imidazo[4,5-c]pyridin-4-one in 20 ml methylene chloride and 4 ml of tetrahydrofuran. The reaction mixture is stirred for eight hours at 60° C., then another 0.3 equivalents Burgess reagent is added. After a further two hours the cooled reaction mixture is combined with aqueous sodium hydrogen carbonate solution and extracted with ethyl acetate. The combined organic phases are dried over magnesium sulphate and evaporated down. The flask residue is chromatographed through a silica gel column with methylene chloride/methanol (1:0 to 10:1) as eluant.

Yield: 1.06 g (60% of theory)

Mass spectrum (ESI⁺): m/z=282, 284 [M+H]⁺

EXAMPLE XIV 2-bromo-7-hydroxy-3-(3-methyl-2-buten-1-yl)-3,5,6,7-tetrahydro-imidazo[4,5-c]pyridin-4-one

90 ml of water and 5.40 g iron powder are added to 4.15 g methyl 2-bromo-5-(1-hydroxy-2-nitro-ethyl)-3-(3-methyl-2-buten-1-yl)-3H-imidazole-4-carboxylate in 270 ml of ethanol. The mixture is refluxed, combined with 36 ml glacial acetic acid and stirred for one and a half hours at reflux temperature. The cooled reaction solution is filtered through Celite. The filtrate is evaporated down, combined with ethanol and made basic with solid potassium carbonate. The mixture is stirred for three hours at 60° C. Then the ethanol is distilled off, the flask residue is combined with water and extracted with ethyl acetate. The combined extracts are dried over magnesium sulphate and evaporated down. The crude product is purified by chromatography over a silica gel column with methylene chloride/methanol (1:1 to 7:1) as eluant.

Yield: 1.62 g (47% of theory)

Mass spectrum (ESI⁺): m/z=300, 302 [M+H]⁺

EXAMPLE XV Methyl 2-bromo-5-(1-hydroxy-2-nitro-ethyl)-3-(3-methyl-2-buten-1-yl)-3H-imidazole-4-carboxylate

35 ml nitromethane are added to 1.14 g caesium carbonate in 15 ml of methanol at ambient temperature. Then the mixture is combined with a solution of 3.50 g methyl 2-bromo-3-(3-methyl-2-buten-1-yl)-5-formyl-3H-imidazole-4-carboxylate in 20 ml of methanol and 5 ml methylene chloride and stirred for 15 minutes at ambient temperature. Then 0.5 ml acetic acid are added and the solution is evaporated down in vacuo. The flask residue is combined with aqueous sodium hydrogen carbonate solution and extracted with ethyl acetate. The combined organic phases are dried over magnesium sulphate and evaporated down.

Yield: 4.15 g (99% of theory)

Mass spectrum (ESI⁺): m/z=362, 364 [M+H]⁺

EXAMPLE XVI 2-[(R)-3-(tert.-butyloxycarbonylamino)-piperidin-1-yl]-3-(2-butyn-1-yl)-5-[(4-oxo-3,4-dihydro-quinazolin-2-yl)methyl]-3,5-dihydro-imidazo[4,5-d]pyridazin-4-one

40 mg sodium methoxide (95%) are added to a solution of 605 mg 2-[(R)-3-(tert.-butyloxycarbonylamino)-piperidin-1-yl]-3-(2-butyn-1-yl)-5-cyanomethyl-3,5-dihydro-imidazo[4,5-d]pyridazin-4-one in 9 ml of methanol. The mixture is stirred for one hour at ambient temperature and then neutralised with 41 μL glacial acetic acid. Then a solution of 195 mg anthranilic acid in 2 ml of methanol is added and the reaction mixture is heated to 70° C. After about two hours a white, voluminous precipitate is formed and the reaction mixture is cooled to ambient temperature. The precipitate formed is suction filtered, washed with cold methanol and dried.

Yield: 234 mg (30% of theory)

Mass spectrum (ESI⁺): m/z=545 [M+H]⁺

Preparation of the final compounds:

EXAMPLE 1

2-(3-amino-piperidin-1-yl)-3-(2-butyn-1-yl)-5-[(dibenzo[b,f][1,4]oxazepin-11-yl)methyl]-3,5-dihydro-imidazo[4,5-d]pyridazin-4-one

0.33 ml trifluoroacetic acid are added to 120 mg 2-[3-(tert.-butyloxycarbonylamino)-piperidin-1-yl]-3-(2-butyn-1-yl)-5-[(dibenzo[b,f][1,4]oxazepin-11-yl)methyl]-3,5-dihydro-imidazo[4,5-d]pyridazin-4-one in 3 ml methylene chloride while cooling with an ice bath. The reaction mixture is stirred overnight at ambient temperature.

For working up it is poured onto cooled saturated potassium carbonate solution and extracted with methylene chloride. The organic phase is separated off and evaporated down. The crude product is purified by chromatography over a silica gel column with methylene chloride/methanol (100:0 to 70:30) as eluant.

Yield: 63 mg (63% of theory)

Mass spectrum (ESI⁺): m/z=494 [M+H]⁺

The following compounds are obtained analogously to Example 1:

-   (1)     2-(3-amino-piperidin-1-yl)-3-(2-butyn-1-yl)-5-[(phenanthridin-6-yl)methyl]-3,5-dihydro-imidazo[4,5-d]pyridazin-4-one

Mass spectrum (ESI⁺): m/z=478 [M+H]⁺

-   (2)     2-(3-amino-piperidin-1-yl)-3-(2-butyn-1-yl)-5-[(phenanthren-9-yl)methyl]-3,5-dihydro-imidazo[4,5-d]pyridazin-4-one

Mass spectrum (ESI⁺): m/z=477 [M+H]⁺

-   (3)     2-((R)-3-amino-piperidin-1-yl)-3-(2-butyn-1-yl)-5-[(phenanthridin-6-yl)methyl]-7-methyl-3,5-dihydro-imidazo[4,5-d]pyridazin-4-one     x trifluoroacetic acid

R_(f) value: 0.45 (Reversed phase ready-made TLC plate (E. Merck), acetonitrile/water/trifluoroacetic acid=50:50:0.1)

Mass spectrum (ESI⁺): m/z=492 [M+H]⁺

-   (4)     2-((R)-3-amino-piperidin-1-yl)-3-(2-butyn-1-yl)-5-[(dibenzo[b,f][1,4]oxazepin-11-yl)methyl]-7-methyl-3,5-dihydro-imidazo[4,5-d]pyridazin-4-one

Carried out with isopropanolic hydrochloric acid (5-6 M) in methylene chloride.

Mass spectrum (ESI⁺): m/z=508 [M+H]⁺

-   (5)     2-((S)-3-amino-piperidin-1-yl)-3-(2-butyn-1-yl)-5-[(dibenzo[b,f][1,4]oxazepin-11-yl)methyl]-3,5-dihydro-imidazo[4,5-d]pyridazin-4-one

Mass spectrum (ESI⁺): m/z=494 [M+H]⁺

-   (6)     2-((R)-3-amino-piperidin-1-yl)-3-(2-butyn-1-yl)-5-[(dibenzo[b,f][1,4]oxazepin-11-yl)methyl]-3,5-dihydro-imidazo[4,5-d]pyridazin-4-one

Mass spectrum (ESI⁺): m/z=494 [M+H]⁺

-   (7)     2-((R)-3-amino-piperidin-1-yl)-3-(2-butyn-1-yl)-5-[(naphtho[2,1-d]oxazol-2-yl)methyl]-3,5-dihydro-imidazo[4,5-d]pyridazin-4-one

R_(f) value: 0.40 (silica gel, methylene chloride/ethanol/conc. aqueous ammonia=90:10:2)

Mass spectrum (ESI⁺): m/z=468 [M+H]⁺

-   (8)     2-((R)-3-amino-piperidin-1-yl)-3-(2-butyn-1-yl)-5-[(naphtho[1,2-d]oxazol-2-yl)methyl]-3,5-dihydro-imidazo[4,5-d]pyridazin-4-one

Mass spectrum (ESI⁺): m/z=468 [M+H]⁺

-   (9)     2-((R)-3-amino-piperidin-1-yl)-3-(2-butyn-1-yl)-5-[(4-oxo-3,4-dihydro-quinazolin-2-yl)methyl]-3,5-dihydro-imidazo[4,5-d]pyridazin-4-one

Mass spectrum (ESI⁺): m/z=445 [M+H]⁺

The following compounds may also be obtained analogously to the foregoing Examples and other methods known from the literature:

No. Name Structural formula  (1) 2-(3-amino-piperidin-1-yl)-3-(2-buten-1-yl)- 5-[(3,4-dihydro-quinolin-2-yl)methyl]-6,7- dimethyl-3,5-dihydro-imidazo[4,5-c]pyridin- 4-one

 (2) 2-(3-amino-piperidin-1-yl)-3-(2-butyn-1-yl)- 5-[(3,4-dihydro-isoquinolin-1-yl)methyl]-7- cyclopropyl-3,5-dihydro-imidazo[4,5- d]pyridazin-4-one

 (3) 2-(3-amino-piperidin-1-yl)-3-(2-butyn-1-yl)- 5-[(3,3-dimethyl-3,4-dihydro-isoquinolin-1- yl)methyl]-3,5-dihydro-imidazo[4,5- d]pyridazin-4-one

 (4) 2-(3-amino-piperidin-1-yl)-3-(2-butyn-1-yl)- 5-[(4,4-dimethyl-3,4-dihydro-isoquinolin-1- yl)methyl]-3,5-dihydro-imidazo[4,5- d]pyridazin-4-one

 (5) 2-(3-amino-piperidin-1-yl)-3-(2-butyn-1-yl)- 5-[(1-methyl-1,4-dihydro-quinazolin-2- yl)methyl]-3,5-dihydro-imidazo[4,5- d]pyridazin-4-one

 (6) 2-(3-amino-piperidin-1-yl)-3-(2-butyn-1-yl)- 5-[(1-methyl-4-oxo-1,4-dihydro-quinazolin- 2-yl)methyl]3,5-dihydro-imidazo[4,5- d]pyridazin-4-one

 (7) 2-(3-amino-piperidin-1-yl)-3-(2-buten-1-yl)- 5-[(5,6,7,8-tetrafluoro-1-methyl-1,4-dihydro- quinazolin-2-yl)methyl]-3,5-dihydro- imidazo[4,5-c]pyridin-4-one

 (8) 2-(3-amino-piperidin-1-yl)-3-(2-buten-1-yl)- 5-[(3,4-dihydro-quinazolin-2-yl)methyl]-3,5- dihydro-imidazo[4,5-d]pyridazin-4-one

 (9) 2-(3-amino-piperidin-1-yl)-3-(2-butyn-1-yl)- 5-[(3-methyl-3,4-dihydro-quinazolin-2- yl)methyl]-3,5-dihydro-imidazo[4,5- d]pyridazin-4-one

(10) 2-(3-amino-piperidin-1-yl)-3-(2-butyn-1-yl)- 5-[(3-methyl-3,4-dihydro-quinazolin-2- yl)methyl]-3,5-dihydro-imidazo[4,5- d]pyridin-4-one

(11) 2-(3-amino-piperidin-1-yl)-3-(1-buten-1-yl)- 5-[(1H-benzo[d][1,2]oxazin-4-yl)methyl]- 3,5-dihydro-imidazo[4,5-d]pyridazin-4-one

(12) 2-(3-amino-piperidin-1-yl)-3-(2-butyn-1-yl)- 5-[(1-oxo-1H-benzo[d][1,2]oxazin-4- yl)methyl]-3,5-dihydro-imidazo[4,5- d]pyridazin-4-one

(13) 2-(3-amino-piperidin-1-yl)-3-(2-butyn-1-yl)- 5-[(4H-benzo[e][1,3]oxazin-2-yl)methyl]- 3,5-dihydro-imidazo[4,5-d]pyridazin-4-one

(14) 2-(3-amino-piperidin-1-yl)-3-(2-buten-1-yl)- 5-[(4,4-dimethyl-4H-benzo[e][1,3]oxazin-2- yl)methyl]-3,5-dihydro-imidazo[4,5- d]pyridazin-4-one

(15) 2-(3-amino-piperidin-1-yl)-3-(2-butyn-1-yl)- 5-[(4-oxo-4H-benzo[e][1,3]oxazin-2- yl)methyl]-3,5-dihydro-imidazo[4,5- d]pyridazin-4-one

(16) 2-(3-amino-piperidin-1-yl)-3-(2-butyn-1-yl)- 5-[(4H-benzo[d][1,3]oxazin-2-yl)methyl]- 3,5-dihydro-imidazo[4,5-d]pyridazin-4-one

(17) 2-(3-amino-piperidin-1-yl)-3-(2-butyn-1-yl)- 5-[(4H-benzo[d][1,3]oxazin-2-yl)methyl]-7- methyl-3,5-dihydro-imidazo[4,5-c]pyridin-4- one

(19) 2-(3-amino-piperidin-1-yl)-3-(2-butyn-1-yl)- 5-[(4,4-dimethyl-4H-benzo[d][1,3]oxazin-2- yl)methyl]-3,5-dihydro-imidazo[4,5- d]pyridazin-4-one

(20) 2-(3-amino-piperidin-1-yl)-3-(2-butyn-1-yl)- 5-[(4-oxo-4H-benzo[d][1,3]oxazin-2- yl)methyl]-3,5-dihydro-imidazo[4,5- d]pyridazin-4-one

(21) 2-(3-amino-piperidin-1-yl)-3-(2-butyn-1-yl)- 5-[(2H-benzo[1,4]oxazin-3-yl)methyl]-3,5- dihydro-imidazo[4,5-d]pyridazin-4-one

(22) 2-(3-amino-piperidin-1-yl)-3-(2-butyn-1-yl)- 5-[(2-oxo-2H-benzo[1,4]oxazin-3- yl)methyl]-3,5-dihydro-imidazo[4,5- d]pyridazin-4-one

(23) 2-(3-amino-piperidin-1-yl)-3-(2-butyn-1-yl)- 5-[(2,2-dimethyl-2H-benzo[1,4]oxazin-3- yl)methyl]-3,5-dihydro-imidazo[4,5- d]pyridazin-4-one

(24) 2-(3-amino-piperidin-1-yl)-3-(2-butyn-1-yl)- 5-[4H-benzo[e][1,3]thiazin-2-yl)methyl]-3,5- dihydro-imidazo[4,5-d]pyridazin-4-one

(25) 2-(3-amino-piperidin-1-yl)-3-(2-butyn-1-yl)- 5-[4,4-dimethyl-4H-benzo[e][1,3]thiazin-2- yl)methyl]-3,5-dihydro-imidazo[4,5- d]pyridazin-4-one

(26) 2-(3-amino-piperidin-1-yl)-3-(2-butyn-1-yl)- 5-[4-oxo-4H-benzo[e][1,3]thiazin-2- yl)methyl]-3,5-dihydro-imidazo[4,5- d]pyridazin-4-one

(27) 2-(3-amino-piperidin-1-yl)-3-(2-butyn-1-yl)- 5-[(4H-benzo[d][1,3]thiazin-2-yl)methyl]- 3,5-dihydro-imidazo[4,5-d]pyridazin-4-one

(28) 2-(3-amino-piperidin-1-yl)-3-(2-butyn-1-yl)- 5-[(2H-benzo[1,4]thiazin-3-yl)methyl]-3,5- dihydro-imidazo[4,5-d]pyridazin-4-one

(29) 2-(3-amino-piperidin-1-yl)-3-(2-butyn-1-yl)- 5-[(2-oxo-2H-benzo[e][1,3]oxazin-4- yl)methyl]-3,5-dihydro-imidazo[4,5- d]pyridazin-4-one

(30) 2-(3-amino-piperidin-1-yl)-3-(2-butyn-1-yl)- 5-[(1-methyl-2,2-dioxo-1H- benzo[c][1,2]thiazin-4-yl)methyl]-3,5- dihydro-imidazo[4,5-d]pyridazin-4-one

(31) 2-(3-amino-piperidin-1-yl)-3-(2-butyn-1-yl)- 5-[(2,3-dihydro-1H-benzo[e][1,4]diazepin-5- yl)methyl]-3,5-dihydro-imidazo[4,5- d]pyridazin-4-one

(32) 2-(3-amino-piperidin-1-yl)-3-(2-butyn-1-yl)- 5-[(2-oxo-2,3-dihydro-1H- benzo[e][1,4]diazepin-5-yl)methyl]-3,5- dihydro-imidazo[4,5-d]pyridazin-4-one

(33) 2-(3-amino-piperidin-1-yl)-3-(2-butyn-1-yl)- 5-[(1-methyl-2,3-dihydro-1H- benzo[e][1,4]diazepin-5-yl)methyl]-3,5- dihydro-imidazo[4,5-d]pyridazin-4-one

(34) 2-(3-amino-piperidin-1-yl)-3-(2-butyn-1-yl)- 5-[(1-methyl-2-oxo-2,3-dihydro-1H- benzo[e][1,4]diazepin-5-yl)methyl]-3,5- dihydro-imidazo[4,5-d]pyridazin-4-one

(35) 2-(3-amino-piperidin-1-yl)-3-(2-butyn-1-yl)- 5-[(4-oxo-4,5-dihydro-3H- benzo[b][1,4]diazepin-2-yl)methyl]-3,5- dihydro-imidazo[4,5-d]pyridazin-4-one

(36) 2-(3-amino-piperidin-1-yl)-3-(2-butyn-1-yl)- 5-[(5-methyl-4-oxo-4,5-dihydro-3H- benzo[b][1,4]diazepin-2-yl)methyl]-3,5- dihydro-imidazo[4,5-d]pyridazin-4-one

(37) 2-(3-amino-piperidin-1-yl)-3-(2-butyn-1-yl)- 5-[5-oxo-4,5-dihydro-3H- benzo[e][1,4]diazepin-2-yl)methyl]-3,5- dihydro-imidazo[4,5-d]pyridazin-4-one

(38) 2-(3-amino-piperidin-1-yl)-3-(2-butyn-1-yl)- 5-[4-methyl-5-oxo-4,5-dihydro-3H- benzo[3][1,4]diazepin-2-yl)methyl]-3,5- dihydro-imidazo[4,5-d]pyridazin-4-one

(39) 2-(3-amino-piperidin-1-yl)-3-(2-butyn-1-yl)- 5-[(2,3-dihydro-benzo[f][1,4]oxazepin-5- yl)methyl]-3,5-dihydro-imidazo[4,5- d]pyridazin-4-one

(40) 2-(3-amino-piperidin-1-yl)-3-(2-butyn-1-yl)- 5-[(3,3-dimethyl-2,3-dihydro- benzo[f][1,4]oxazepin-5-yl)methyl]-3,5- dihydro-imidazo[4,5-d]pyridazin-4-one

(41) 2-(3-amino-piperidin-1-yl)-3-(2-butyn-1-yl)- 5-[(2,2-dimethyl-2,3-dihydro- benzo[f][1,4]oxazepin-5-yl)methyl]-7- methyl-3,5-dihydro-imidazo[4,5-d]pyridazin- 4-one

(42) 2-(3-amino-piperidin-1-yl)-3-(2-butyn-1-yl)- 5-[(2,3-dihydro-benzo[b][1,4]oxazepin-4- yl)methyl]-7-methyl-3,5-dihydro- imidazo[4,5-d]pyridazin-4-one

(43) 2-(3-amino-piperidin-1-yl)-3-(2-butyn-1-yl)- 5-[(6,6-dimethyl-2,3-dihydro- benzo[b][1,4]oxazepin-4-yl)methyl]-7- methyl-3,5-dihydro-imidazo[4,5-d]pyridazin- 4-one

(44) 2-(3-amino-piperidin-1-yl)-3-(2-butyn-1-yl)- 5-[(2,3-dihydro-benzo[b][1,4]thiazepin-4- yl)methyl]-7-methyl-3,5-dihydro- imidazo[4,5-d]pyridazin-4-one

(45) 2-(3-amino-piperidin-1-yl)-3-(2-butyn-1-yl)- 5-[(2,2-dimethyl-2,3-dihydro- benzo[b][1,4]thiazepin-4-yl)methyl]-7- methyl-3,5-dihydro-imidazo[4,5-d]pyridazin- 4-one

(46) 2-(3-amino-piperidin-1-yl)-3-(2-butyn-1-yl)- 5-[(2,3-dihydro-benzo[f][1,4]thiazepin-5- yl)methyl]-7-methyl-3,5-dihydro- imidazo[4,5-d]pyridazin-4-one

(47) 2-(3-amino-piperidin-1-yl)-3-(2-butyn-1-yl)- 5-[(5-oxo-4,5-dihydro- benzo[f][1,3,4]oxadiazepin-2-yl)methyl]-7- methyl-3,5-dihydro-imidazo[4,5-d]pyridazin- 4-one

(48) 2-(3-amino-piperidin-1-yl)-3-(2-butyn-1-yl)- 5-[(11H-dibenzo[b,e]azepin-6-yl)methyl]-7- ethyl-3,5-dihydro-imidazo[4,5-d]pyridazin-4- one

(49) 2-(3-amino-piperidin-1-yl)-3-(2-butyn-1-yl)- 5-[(11H-dibenzo[b,e]azepin-6-yl)methyl]-7- cyanomethyl-3,5-dihydro-imidazo[4,5- d]pyridazin-4-one

(50) 2-(3-amino-piperidin-1-yl)-3-(2-butyn-1-yl)- 5-[(11,11-difluoro-11H-dibenzo[b,e]azepin- 6-yl)methyl]-3,5-dihydro-imidazo[4,5- c]pyridin-4-one

(51) 2-(3-amino-piperidin-1-yl)-3-(2-butyn-1-yl)- 5-[(11-oxo-11H-dibenzo[b,e]azepin-6- yl)methyl]-7-(2-cyanoethyl)-3,5-dihydro- imidazo[4,5-d]pyridazin-4-one

(52) 2-(3-amino-piperidin-1-yl)-3-(1-buten-1-yl)- 5-[(11H-benzo[e]pyrido[3,2-b]azepin-6- yl)methyl]-7-methyl-3,5-dihydro- imidazo[4,5-d]pyridazin-4-one

(53) 2-(3-amino-piperidin-1-yl-(2-butyn-1-yl)-5- [(5H-1,9,10-triaza-dibenzo[a,d]cyclohepten- 11-yl)methyl]-3,5-dihydro-imidazo[4,5- d]pyridin-4-one

(54) 2-(3-amino-piperidin-1-yl)-3-(2-buten-1-yl)- 5-[(5-methyl-5H-dibenzo[b,e][1,4]diazepin- 11-yl)methyl]-7-methyl-3,5-dihydro- imidazo[4,5-d]pyridazin-4-one

(55) 2-(3-amino-piperidin-1-yl)-3-(1-buten-1-yl)- 5-[(dibenzo[b,f][1,4]oxazepin-11-yl)methyl]- 3,5-dihydro-imidazo[4,5-c]pyridin-4-one

(56) 2-(3-amino-piperidin-1-yl)-3-(2-butyn-1-yl)- 5-[(dibenzo[b,f][1,4]thiazepin-11-yl)methyl]- 7-methyl-3,5-dihydro-imidazo[4,5- d]pyridazin-4-one

(57) 2-(3-amino-piperidin-1-yl)-3-(1-buten-1-yl)- 5-[(dibenzo[b,f][1,4]thiazepin-11-yl)methyl]- 3,5-dihydro-imidazo[4,5-c]pyridin-4-one

(58) 2-(3-amino-piperidin-1-yl)-3-(2-butyn-1-yl)- 5-[(5-oxo-dibenzo[b,f][1,4]thiazepin-11- yl)methyl]-7-methyl-3,5-dihydro- imidazo[4,5-d]pyridazin-4-one

(59) 2-(3-amino-piperidin-1-yl)-3-(2-butyn-1-yl)- 5-[(5,5-dioxo-dibenzo[b,f][1,4]-thiazepin-11- yl)methyl]-7-methyl-3,5-dihydro- imidazo[4,5-d]pyridazin-4-one

(60) 2-(3-amino-piperidin-1-yl)-3-(2-butyn-1-yl)- 5-[(5H-dibenzo[a,d]cyclohepten-10- yl)methyl]-7-methyl-3,5-dihydro- imidazo[4,5-d]pyridazin-4-one

(61) 2-(3-amino-piperidin-1-yl)-3-(2-butyn-1-yl)- 5-[(5-methyl-5H-dibenzo[b,f]azepin-10- yl)methyl]-7-trifluoromethyl-3,5-dihydro- imidazo[4,5-d]pyridazin-4-one

(62) 2-(3-amino-piperidin-1-yl)-3-(3-methyl-2- buten-1-yl)-5-[(phenanthridin-6-yl)methyl]- 7-methyl-3,5-dihydro-imidazo[4,5- d]pyridazin-4-one

(63) 2-(3-amino-piperidin-1-yl)-3-(2-buten-1-yl)- 5-[(phenanthridin-6-yl)methyl]-7-methyl-3,5- dihydro-imidazo[4,5-d]pyridazin-4-one

(64) 2-(3-amino-piperidin-1-yl)-3-(1-buten-1-yl)- 5-[(phenanthridin-6-yl)methyl]-7-methyl-3,5- dihydro-imidazo[4,5-d]pyridazin-4-one

(65) 2-(3-amino-piperidin-1-yl)-3-[(1- cyclopenten-1-yl)methyl]-5-[(phenanthridin- 6-yl)methyl]-7-methyl-3,5-dihydro- imidazo[4,5-d]pyridazin-4-one

(66) 2-(3-amino-piperidin-1-yl)-3-(1-buten-1-yl)- 5-[(phenanthridin-6-yl)methyl]-3,5-dihydro- imidazo[4,5-c]pyridin-4-one

(67) 2-(3-amino-piperidin-1-yl)-3-(2-butyn-1-yl)- 5-[(benzo[c][1,5]naphthyridin-6-yl)methyl]- 7-cyclopropyl-3,5-dihydro-imidazo[4,5- d]pyridazin-4-one

(68) 2-(3-amino-piperidin-1-yl)-3-(2-butyn-1-yl)- 5-[(benzo[h][1,6]naphthyridin-5-yl)methyl]- 3,5-dihydro-imidazo[4,5-d]pyridazin-4-one

(69) 2-(3-amino-piperidin-1-yl)-3-(2-butyn-1-yl)- 5-[(benzo[c][1,8]naphthyridin-6-yl)methyl]- 3,5-dihydro-imidazo[4,5-d]pyridazin-4-one

(70) 2-(3-amino-piperidin-1-yl)-3-(2-butyn-1-yl)- 5-[(5-benzo[f][1,7]naphthyridin-5- yl)methyl]-3,5-dihydro-imidazo[4,5- c]pyridin-4-one

(71) 2-(3-amino-piperidin-1-yl)-3-(2-butyn-1-yl)- 5-[(1,5,9-triaza-phenanthren-10-yl)methyl]- 3,5-dihydro-imidazo[4,5-c]pyridin-4-one

(72) 2-(3-amino-piperidin-1-yl)-3-(2-butyn-1-yl)- 5-[(1,2,3,4-tetrahydrophenanthridin-6- yl)methyl]-3,5-dihydro-imidazo[4,5- c]pyridin-4-one

(73) 2-(3-amino-piperidin-1-yl)-3-(2-butyn-1-yl)- 5-[(1,2,3,4,4a,10b-hexahydro-phenanthridin- 6-yl)methyl]-3,5-dihydro-imidazo[4,5- c]pyridin-4-one

(74) 2-(3-amino-piperidin-1-yl)-3-(2-butyn-1-yl)- 5-[(2,3-dihydro-1H-4-aza- cyclopenta[a]naphth-5-yl)methyl]-3,5- dihydro-imidazo[4,5-c]pyridin-4-one

(75) 2-(3-amino-piperidin-1-yl)-3-(2-butyn-1-yl)- 5-[(8,9,10,11-tetrahydro-7H-6-aza- cyclohepta[a]naphth-5-yl)methyl]-3,5- dihydro-imidazo[4,5-c]pyridin-4-one

(76) 2-(3-amino-piperidin-1-yl)-3-(2-butyn-1-yl)- 5-[(2,3-dihydro-1H-4-oxo-10-aza- phenanthren-9-yl)methyl]-3,5-dihydro- imidazo[4,5-c]pyridin-4-one

(77) 2-(3-amino-piperidin-1-yl)-3-(2-butyn-1-yl)- 5-[(1-oxo-2,3-dihydro-1H-4-oxo-10-aza- phenanthren-9-yl)methyl]-3,5-dihydro- imidazo[4,5-c]pyridin-4-one

(78) 2-(3-amino-piperidin-1-yl)-3-(2-butyn-1-yl)- 5-[(10-cyanophenanthren-9-yl)methyl]-3,5- dihydro-imidazo[4,5-c]pyridin-4-one

(79) 2-(3-amino-piperidin-1-yl)-3-(2-butyn-1-yl)- 5-[(benzo[h]quinolin-6-yl)methyl]-3,5- dihydro-imidazo[4,5-c]pyridin-4-one

(80) 2-(3-amino-piperidin-1-yl)-3-(2-butyn-1-yl)- 5-[(benzo[f]quinolin-6-yl)methyl]-3,5- dihydro-imidazo[4,5-d]pyridazin-4-one

(81) 2-(3-amino-piperidin-1-yl)-3-(2-butyn-1-yl)- 5-[(benzo[f]quinoxalin-6-)methyl]-3,5- dihydro-imidazo[4,5-d]pyridazin-4-one

(82) 2-(3-amino-piperidin-1-yl)-3-(2-butyn-1-yl)- 5-[(5H-benzo[e]pyrrolo[1,2-a][1,4]diazepin- 11-yl)methyl]-7-methyl-3,5-dihydro- imidazo[4,5-d]pyridazin-4-one

(83) 2-(3-amino-piperidin-1-yl)-3-(2-butyn-1-yl)- 5-[(thieno[3,2-b][1,4]benzoxazepin-9- yl)methyl]-7-trifluoromethyl-3,5-dihydro- imidazo[4,5-d]pyridazin-4-one

(84) 2-(3-amino-piperidin-1-yl)-3-(2-butyn-1-yl)- 5-[(thieno[3,2-b][1,4]benzoxazepin-9- yl)methyl]-3,5-dihydro-imidazo[4,5- c]pyridin-4-one

(85) 2-(3-amino-piperidin-1-yl)-3-(2-butyn-1-yl)- 5-[(5H-dibenzo[d,f][1,3]diazepin-6- yl)methyl]-7-methyl-3,5-dihydro- imidazo[4,5-d]pyridazin-4-one

(86) 2-(3-amino-piperidin-1-yl)-3-(2-butyn-1-yl)- 5-[(5-methyl-5H-dibenzo[d,f][1,3]diazepin- 6-yl)methyl]-3,5-dihydro-imidazo[4,5- c]pyridin-4-one

(87) 2-(3-amino-piperidin-1-yl)-3-(3-methylbut-2- en-1-yl)-5-[(5-oxa-7-aza- dibenzo[a,c]cyclohepten-6-yl)methyl]-7- methyl-3,5-dihydro-imidazo[4,5-c]pyridin-4- one

(88) 2-(3-amino-piperidin-1-yl)-3-(2-butyn-1-yl)- 5-[(naphtho[1,2-d]thiazol-2-yl)methyl]-3,5- dihydro-imidazo[4,5-d]pyridazin-4-one

(89) 2-(3-amino-piperidin-1-yl)-3-(2-butyn-1-yl)- 5-[(naphtho[2,1-d]thiazol-2-yl)methyl]-3,5- dihydro-imidazo[4,5-d]pyridazin-4-one

(90) 2-(3-amino-piperidin-1-yl)-3-(2-butyn-1-yl)- 5-[(3H-naphtho[1,2-d]imidazol-2-yl)methyl]- 3,5-dihydro-imidazo[4,5-d]pyridazin-4-one

(91) 2-(3-amino-piperidin-1-yl)-3-(2-butyn-1-yl)- 5-[(naphtho[1,2-b]furan-2-yl)methyl]-3,5- dihydro-imidazo[4,5-d]pyridazin-4-one

(92) 2-(3-amino-piperidin-1-yl)-3-(2-butyn-1-yl)- 5-[(naphtho[2,1-b]furan-2-yl)methyl]-3,5- dihydro-imidazo[4,5-d]pyridazin-4-one

(93) 2-(3-amino-piperidin-1-yl)-3-(2-butyn-1-yl)- 5-[(2-methyl-furo[3,2-c]isoquinolin-5- yl)methyl]-3,5-dihydro-imidazo[4,5- c]pyridin-4-one

(94) 2-(3-amino-piperidin-1-yl)-3-(2-butyn-1-yl)- 5-[(pyrazolo[1,5-c]quinazolin-5-yl)methyl]- 3,5-dihydro-imidazo[4,5-d]pyridazin-4-one

(95) 2-(3-amino-piperidin-1-yl)-3-(2-butyn-1-yl)- 5-[(1H-perimidin-2-yl)methyl]-3,5-dihydro- imidazo[4,5-d]pyridazin-4-one

EXAMPLE 2 Coated Tablets Containing 75 mg of Active Substance

1 tablet core contains: active substance 75.0 mg calcium phosphate 93.0 mg corn starch 35.5 mg polyvinylpyrrolidone 10.0 mg hydroxypropylmethylcellulose 15.0 mg magnesium stearate  1.5 mg 230.0 mg  Preparation:

The active substance is mixed with calcium phosphate, corn starch, polyvinylpyrrolidone, hydroxypropylmethylcellulose and half the specified amount of magnesium stearate. Blanks 13 mm in diameter are produced in a tablet-making machine and these are then rubbed through a screen with a mesh size of 1.5 mm using a suitable machine and mixed with the rest of the magnesium stearate. This granulate is compressed in a tablet-making machine to form tablets of the desired shape.

-   -   Weight of core: 230 mg     -   die: 9 mm, convex

The tablet cores thus produced are coated with a film consisting essentially of hydroxypropylmethylcellulose. The finished film-coated tablets are polished with beeswax.

-   -   Weight of coated tablet: 245 mg.

EXAMPLE 3 Tablets Containing 100 mg of Active Substance

Composition: 1 tablet contains: active substance 100.0 mg lactose 80.0 mg corn starch 34.0 mg polyvinylpyrrolidone 4.0 mg magnesium stearate 2.0 mg 220.0 mg Method of Preparation:

The active substance, lactose and starch are mixed together and uniformly moistened with an aqueous solution of the polyvinylpyrrolidone. After the moist composition has been screened (2.0 mm mesh size) and dried in a rack-type drier at 50° C. it is screened again (1.5 mm mesh size) and the lubricant is added. The finished mixture is compressed to form tablets.

-   -   Weight of tablet: 220 mg     -   Diameter: 10 mm, biplanar, facetted on both sides and notched on         one side.

EXAMPLE 4 Tablets Containing 150 mg of Active Substance

Composition: 1 tablet contains: active substance 150.0 mg  powdered lactose 89.0 mg corn starch 40.0 mg colloidal silica 10.0 mg polyvinylpyrrolidone 10.0 mg magnesium stearate  1.0 mg 300.0 mg  Preparation:

The active substance mixed with lactose, corn starch and silica is moistened with a 20% aqueous polyvinylpyrrolidone solution and passed through a screen with a mesh size of 1.5 mm. The granules, dried at 45° C., are passed through the same screen again and mixed with the specified amount of magnesium stearate. Tablets are pressed from the mixture.

-   -   Weight of tablet: 300 mg     -   die: 10 mm, flat

EXAMPLE 5 Hard Gelatine Capsules Containing 150 mg of Active Substance

1 capsule contains: active substance 150.0 mg corn starch (dried) approx. 80.0 mg lactose (powdered) approx. 87.0 mg magnesium stearate 3.0 mg approx. 420.0 mg Preparation:

The active substance is mixed with the excipients, passed through a screen with a mesh size of 0.75 mm and homogeneously mixed using a suitable apparatus. The finished mixture is packed into size 1 hard gelatine capsules.

-   -   Capsule filling: approx. 320 mg     -   Capsule shell: size 1 hard gelatine capsule.

EXAMPLE 6 Suppositories Containing 150 mg of Active Substance

1 suppository contains: active substance 150.0 mg polyethyleneglycol 1500 550.0 mg polyethyleneglycol 6000 460.0 mg polyoxyethylene sorbitan monostearate 840.0 mg 2,000.0 mg  Preparation:

After the suppository mass has been melted the active substance is homogeneously distributed therein and the melt is poured into chilled moulds.

EXAMPLE 7 Suspension Containing 50 mg of Active Substance

100 ml of suspension contain: active substance 1.00 g carboxymethylcellulose-Na-salt 0.10 g methyl p-hydroxybenzoate 0.05 g propyl p-hydroxybenzoate 0.01 g glucose 10.00 g glycerol 5.00 g 70% sorbitol solution 20.00 g flavouring 0.30 g dist. water ad 100 ml Preparation:

The distilled water is heated to 70° C. The methyl and propyl p-hydroxybenzoates together with the glycerol and sodium salt of carboxymethylcellulose are dissolved therein with stirring. The solution is cooled to ambient temperature and the active substance is added and homogeneously dispersed therein with stirring. After the sugar, the sorbitol solution and the flavouring have been added and dissolved, the suspension is evacuated with stirring to eliminate air.

-   -   5 ml of suspension contain 50 mg of active substance.

EXAMPLE 8 Ampoules Containing 10 mg Active Substance

Composition: active substance 10.0 mg 0.01 N hydrochloric acid q.s. double-distilled water ad 2.0 ml Preparation:

The active substance is dissolved in the necessary amount of 0.01 N HCl, made isotonic with common salt, filtered sterile and transferred into 2 ml ampoules.

EXAMPLE 9 Ampoules Containing 50 mg of Active Substance

Composition: active substance 50.0 mg 0.01 N hydrochloric acid q.s. double-distilled water ad 10.0 ml Preparation:

The active substance is dissolved in the necessary amount of 0.01 N HCl, made isotonic with common salt, filtered sterile and transferred into 10 ml ampoules. 

1. A compound of formula (I)

wherein R¹ denotes a C₁₋₃-alkyl group substituted by a group R_(a), where R_(a) denotes a 3,4-dihydro-quinolinyl, 3,4-dihydro-isoquinolinyl, 1,4-dihydro-quinazolinyl, 3,4-dihydro-quinazolinyl, 1H-benzo[d][1,2]oxazinyl, 4H-benzo[e][1,3]oxazinyl, 4H-benzo[d][1,3]oxazinyl or 2H-benzo[1,4]oxazinyl group, wherein in each case in the benzo moiety one to three methyne groups may each be replaced by a nitrogen atom and in the heterocyclyl moiety a methylene group may be replaced by a carbonyl group, a 4H-benzo[e][1,3]thiazinyl, 4H-benzo[d][1,3]thiazinyl or 2H-benzo[1,4]thiazinyl group wherein in each case in the benzo moiety one to three methyne groups may each be replaced by a nitrogen atom and in the heterocyclyl moiety a methylene group may be replaced by a carbonyl group and the sulphur atom may be replaced by a sulphinyl or sulphonyl group, a 2-oxo-2H-benzo[e][1,3]oxazinyl or 2,2-dioxo-1H-benzo[c][1,2]thiazinyl group wherein in each case in the benzo moiety one to three methyne groups may each be replaced by a nitrogen atom, a 2,3-dihydro-1H-benzo[e][1,4]diazepinyl, 4,5-dihydro-3H-benzo[b][1,4]diazepinyl or 5-oxo-4,5-dihydro-3H-benzo[e][1,4]diazepinyl group wherein in each case in the benzo moiety one to three methyne groups may each be replaced by a nitrogen atom and in the heterocyclyl moiety a methylene group may be replaced by a carbonyl group, a 2,3-dihydro-benzo[f][1,4]oxazepinyl or 2,3-dihydro-benzo[b][1,4]oxazepinyl group wherein in each case in the benzo moiety one to three methyne groups may each be replaced by a nitrogen atom and in the heterocyclyl moiety a methylene group may be replaced by a carbonyl group, a 2,3-dihydro-benzo[b][1,4]thiazepinyl or 2,3-dihydro-benzo[f][1,4]thiazepinyl group wherein in each case in the benzo moiety one to three methyne groups may each be replaced by a nitrogen atom and in the heterocyclyl moiety a methylene group may be replaced by a carbonyl group and the sulphur atom may be replaced by a sulphinyl or sulphonyl group, a 5-oxo-4,5-dihydro-benzo[f][1,3,4]oxadiazepinyl group wherein in the benzo moiety one to three methyne groups may each be replaced by a nitrogen atom, a 11H-dibenzo[b,e]azepinyl or 5H-dibenzo[a,d]cycloheptenyl group wherein in each case in the benzo moiety one to three methyne groups may each be replaced by a nitrogen atom and the methylene group in the heterocyclyl moiety may be replaced by an oxygen or sulphur atom, a carbonyl, sulphinyl or sulphonyl group or by an imino group substituted by R_(x), where R_(x) denotes a hydrogen atom or a C₁₋₄-alkyl, C₂₋₄-alkenyl, C₂₋₄-alkynyl, C₃₋₆-cycloalkyl, C₃₋₆-cycloalkyl-C₁₋₃-alkyl, aryl, aryl-C₁₋₃-alkyl, hydroxy-C₂₋₄-alkyl, C₁₋₃-alkyloxy-C₂₋₄-alkyl, C₃₋₆-cycloalkyloxy-C₂₋₄-alkyl, amino-C₂₋₄-alkyl, C₁₋₃-alkylamino-C₂₋₄-alkyl, di-(C₁₋₃-alkyl)-amino-C₂₋₄-alkyl, C₁₋₃-alkyl-carbonyl, C₁₋₃-alkyloxy-carbonyl, C₁₋₃-alkyloxy-carbonyl-C₁₋₃-alkyl, aryl-carbonyl, C₁₋₃-alkyl-sulphonyl or aryl-sulphonyl group, a phenanthridinyl group wherein in the benzo moiety one to three methyne groups may each be replaced by a nitrogen atom, and a 1,2,3,4-tetrahydro-phenanthridinyl, 1,2,3,4,4a,10b-hexahydro-phenanthridinyl, 2,3-dihydro-1H-4-aza-cyclopenta[a]naphthyl or a 8,9,10,11-tetrahydro-7H-6-aza-cyclohepta[a]naphthyl group wherein in each case in the benzo moiety one to three methyne groups may each be replaced by a nitrogen atom and one or two methylene groups may each be replaced by an oxygen atom or a carbonyl group, while, if two methylene groups are each replaced by an oxygen atom, the oxygen atoms must be separated from one another by at least two methylene units, a phenanthrenyl group wherein in each case one to three of the methyne groups in position 1 to 4 and 5 to 8 may each be replaced by a nitrogen atom, a 1,2,3,4-tetrahydro-phenanthrenyl or a 1,2,3,4,5,6,7,8-octahydro-phenanthrenyl group wherein in each case one or two of the methylene groups in position 1 to 4 and 5 to 8 may each be replaced by an oxygen atom or a carbonyl group, while, if two methylene groups are each replaced by an oxygen atom, the oxygen atoms must be separated from one another by at least two methylene units, a 5H-benzo[e]pyrrolo[1,2-a][1,4]diazepinyl, thieno[3,2-b][1,4]benzoxazepinyl, 5H-dibenzo[d,f][1,3]diazepinyl or a 5-oxa-7-aza-dibenzo[a,c]cycloheptenyl group wherein in each case in the benzo moiety one to three methyne groups may each be replaced by a nitrogen atom, a naphtho[1,2-d]oxazolyl, naphtho[2,1-d]oxazolyl, naphtho[1,2-d]thiazolyl, naphtho[2,1-d]thiazolyl, naphtho[1,2-d]imidazolyl, naphtho[1,2-b]furanyl or naphtho[2,1-b]furanyl group wherein in each case in the naphthyl moiety one to three methyne groups may each be replaced by a nitrogen atom, or a furo[3,2-c]isoquinolinyl, pyrazolo[1,5-c]quinazolinyl or 1H-perimidinyl group, while the methylene and methyne groups of the above mentioned radicals R_(a) may be substituted by the groups R¹⁰ to R¹³ and additionally by a C₁₋₃-alkyl group and the imino groups of the above mentioned radicals R_(a) may be substituted by the groups R_(x) as hereinbefore defined and R¹⁰ denotes a hydrogen atom, a fluorine, chlorine, bromine or iodine atom, a C₁₋₄-alkyl, hydroxy, or C₁₋₄-alkyloxy group, a nitro, amino, C₁₋₃-alkylamino, di-(C₁₋₃-alkyl)amino, cyano-C₁₋₃-alkylamino, N-(cyano-C₁₋₃-alkyl)-N—(C₁₋₃-alkyl)-amino, C₁₋₃-alkyloxy-carbonyl-C₁₋₃-alkylamino, pyrrolidin-1-yl, piperidin-1-yl, morpholin-4-yl, piperazin-1-yl, or 4-(C₁₋₃-alkyl)-piperazin-1-yl group, a C₁₋₃-alkyl-carbonylamino, arylcarbonylamino, aryl-C₁₋₃-alkyl-carbonylamino, C₁₋₃-alkyloxy-carbonylamino, aminocarbonylamino, C₁₋₃-alkylaminocarbonylamino, di-(C₁₋₃-alkyl)aminocarbonylamino, pyrrolidin-1-yl-carbonylamino, piperidin-1-yl-carbonylamino, morpholin-4-yl-carbonylamino, piperazin-1-yl-carbonylamino or 4-(C₁₋₃-alkyl)-piperazin-1-yl-carbonylamino, C₁₋₃-alkyl-sulphonylamino, bis-(C₁₋₃-alkylsulphonyl)-amino, aminosulphonylamino, C₁₋₃-alkylamino-sulphonylamino, di-(C₁₋₃-alkyl)amino-sulphonylamino, pyrrolidin-1-yl-sulphonylamino, piperidin-1-yl-sulphonylamino, morpholin-4-yl-sulphonylamino, piperazin-1-yl-sulphonylamino or 4-(C₁₋₃-alkyl)-piperazin-1-yl-sulphonylamino, (C₁₋₃-alkylamino)thiocarbonylamino, (C₁₋₃-alkyloxy-carbonyl-amino)carbonylamino, arylsulphonylamino or aryl-C₁₋₃-alkyl-sulphonyl-amino group, an N—(C₁₋₃-alkyl)-C₁₋₃-alkyl-carbonylamino, N—(C₁₋₃-alkyl)-arylcarbonyl-amino, N—(C₁₋₃-alkyl)-aryl-C₁₋₃-alkyl-carbonylamino, N—(C₁₋₃-alkyl)-C₁₋₃-alkyloxy-carbonylamino, N-(aminocarbonyl)-C₁₋₃-alkylamino, N—(C₁₋₃-alkyl-aminocarbonyl)-C₁₋₃-alkylamino, N-[di-(C₁₋₃-alkyl)aminocarbonyl]-C₁₋₃-alkylamino, N—(C₁₋₃-alkyl)-C₁₋₃-alkyl-sulphonylamino, N—(C₁₋₃-alkyl)-arylsulphonylamino, or N—(C₁₋₃-alkyl)-aryl-C₁₋₃-alkyl-sulphonylamino group, a 2-oxo-imidazolidin-1-yl, 2,4-dioxo-imidazolidin-1-yl, 2,5-dioxo-imidazolidin-1-yl or 2-oxo-hexahydropyrimidin-1-yl group wherein the nitrogen atom in the 3 position may be substituted in each case by a methyl or ethyl group, a cyano, carboxy, C₁₋₃-alkyloxy-carbonyl, aminocarbonyl, C₁₋₃-alkyl-aminocarbonyl, di-(C₁₋₃-alkyl)-aminocarbonyl, pyrrolidin-1-yl-carbonyl, piperidin-1-yl-carbonyl, morpholin-4-yl-carbonyl, piperazin-1-yl-carbonyl or 4-(C₁₋₃-alkyl)-piperazin-1-yl-carbonyl group, a C₁₋₃-alkyl-carbonyl or an arylcarbonyl group, a carboxy-C₁₋₃-alkyl, C₁₋₃-alkyloxy-carbonyl-C₁₋₃-alkyl, cyano-C₁₋₃-alkyl, aminocarbonyl-C₁₋₃-alkyl, C₁₋₃-alkyl-aminocarbonyl-C₁₋₃-alkyl, di-(C₁₋₃-alkyl)-aminocarbonyl-C₁₋₃-alkyl, pyrrolidin-1-yl-carbonyl-C₁₋₃-alkyl, piperidin-1-yl-carbonyl-C₁₋₃-alkyl, morpholin-4-yl-carbonyl-C₁₋₃-alkyl, piperazin-1-yl-carbonyl-C₁₋₃-alkyl or 4-(C₁₋₃-alkyl)-piperazin-1-yl-carbonyl-C₁₋₃-alkyl group, a carboxy-C₁₋₃-alkyloxy, C₁₋₃-alkyloxy-carbonyl-C₁₋₃-alkyloxy, cyano-C₁₋₃-alkyloxy, aminocarbonyl-C₁₋₃-alkyloxy, C₁₋₃-alkyl-aminocarbonyl-C₁₋₃-alkyloxy, di-(C₁₋₃-alkyl)-aminocarbonyl-C₁₋₃-alkyloxy, pyrrolidin-1-yl-carbonyl-C₁₋₃-alkyloxy, piperidin-1-yl-carbonyl-C₁₋₃-alkyloxy, morpholin-4-yl-carbonyl-C₁₋₃-alkyloxy, piperazin-1-yl-carbonyl-C₁₋₃-alkyloxy or 4-(C₁₋₃-alkyl)-piperazin-1-yl-carbonyl-C₁₋₃-alkyloxy group, a hydroxy-C₁₋₃-alkyl, C₁₋₃-alkyloxy-C₁₋₃-alkyl, amino-C₁₋₃-alkyl, C₁₋₃-alkylamino-C₁₋₃-alkyl, di-(C₁₋₃-alkyl)-amino-C₁₋₃-alkyl, pyrrolidin-1-yl-C₁₋₃-alkyl, piperidin-1-yl-C₁₋₃-alkyl, morpholin-4-yl-C₁₋₃-alkyl, piperazin-1-yl-C₁₋₃-alkyl or 4-(C₁₋₃-alkyl)-piperazin-1-yl-C₁₋₃-alkyl group, a hydroxy-C₁₋₃-alkyloxy, C₁₋₃-alkyloxy-C₁₋₃-alkyloxy, C₁₋₃-alkylsulphanyl-C₁₋₃-alkyloxy, C₁₋₃-alkylsulphinyl-C₁₋₃-alkyloxy, C₁₋₃-alkylsulphonyl-C₁₋₃-alkyloxy, amino-C₁₋₃-alkyloxy, C₁₋₃-alkylamino-C₁₋₃-alkyloxy, di-(C₁₋₃-alkyl)-amino-C₁₋₃-alkyloxy, pyrrolidin-1-yl-C₁₋₃-alkyloxy, piperidin-1-yl-C₁₋₃-alkyloxy, morpholin-4-yl-C₁₋₃-alkyloxy, piperazin-1-yl-C₁₋₃-alkyloxy or 4-(C₁₋₃-alkyl)-piperazin-1-yl-C₁₋₃-alkyloxy group, a mercapto, C₁₋₃-alkylsulphanyl, C₁₋₃-alkysulphinyl, C₁₋₃-alkylsulphonyl, C₁₋₃-alkylsulphonyloxy, arylsulphonyloxy, trifluoromethylsulphanyl, trifluoromethylsulphinyl or trifluoromethylsulphonyl group, a sulpho, aminosulphonyl, C₁₋₃-alkyl-aminosulphonyl, di-(C₁₋₃-alkyl)-aminosulphonyl, pyrrolidin-1-yl-sulphonyl, piperidin-1-yl-sulphonyl, morpholin-4-yl-sulphonyl, piperazin-1-yl-sulphonyl or 4-(C₁₋₃-alkyl)-piperazin-1-yl-sulphonyl group, a methyl or methoxy group substituted by 1 to 3 fluorine atoms, an ethyl or ethoxy group substituted by 1 to 5 fluorine atoms, a C₂₋₄-alkenyl or C₂₋₄-alkynyl group, a C₃₋₄-alkenyloxy or C₃₋₄-alkynyloxy group, a C₃₋₆-cycloalkyl or C₃₋₆-cycloalkyloxy group, a C₃₋₆-cycloalkyl-C₁₋₃-alkyl or C₃₋₆-cycloalkyl-C₁₋₃-alkyloxy group or an aryl, aryloxy, aryl-C₁₋₃-alkyl or aryl-C₁₋₃-alkyloxy group, R¹¹ and R¹², which may be identical or different, in each case represent a hydrogen atom, a fluorine, chlorine, bromine or iodine atom, a C₁₋₃-alkyl, trifluoromethyl, hydroxy, C₁₋₃-alkyloxy or cyano group, or R¹¹ together with R¹², if these are bound to adjacent carbon atoms, also denotes a methylenedioxy, difluoromethylenedioxy, ethylenedioxy or a straight-chain C₃₋₅-alkylene group and R¹³ denotes a hydrogen atom, a fluorine, chlorine or bromine atom, a trifluoromethyl, C₁₋₃-alkyl or C₁₋₃-alkyloxy group, R² denotes a hydrogen atom, a C₁₋₆-alkyl group, or a C₃₋₆-cycloalkyl group, Y denotes a group of formula C—R⁵, while R⁵ is defined like R² and in each case one of the two groups R² and R⁵ must be a hydrogen atom or a C₁₋₃-alkyl group, R³ denotes a C₃₋₈-alkyl group, a C₃₋₈-alkenyl group, or a C₃₋₈-alkynyl group, and R⁴ denotes a piperidin-1-yl group which is substituted in the 3 position by an amino, C₁₋₃-alkylamino or a di-(C₁₋₃-alkyl)amino, while by the aryl groups mentioned in the definition of the above groups are meant phenyl or naphthyl groups which may be mono- or disubstituted by R_(h), while the substituents may be identical or different and R_(h) denotes a fluorine, chlorine, bromine or iodine atom, a trifluoromethyl, cyano, nitro, amino, aminocarbonyl, aminosulphonyl, methylsulphonyl, acetylamino, methylsulphonylamino, C₁₋₃-alkyl, cyclopropyl, ethenyl, ethynyl, hydroxy, C₁₋₃-alkyloxy, difluoromethoxy or trifluoromethoxy group, by the heteroaryl groups mentioned in the definition of the above groups are meant a pyrrolyl, furanyl, thienyl, pyridyl, indolyl, benzofuranyl, benzothiophenyl, quinolinyl or isoquinolinyl group, or a pyrrolyl, furanyl, thienyl or pyridyl group, wherein one or two methyne groups are replaced by nitrogen atoms, or an indolyl, benzofuranyl, benzothiophenyl, quinolinyl or isoquinolinyl group, wherein one to three methyne groups are replaced by nitrogen atoms, and the above mentioned heteroaryl groups may be mono- or disubstituted by R_(h), while the substituents may be identical or different and R_(h) is as hereinbefore defined, while, unless otherwise stated, the above mentioned alkyl, alkenyl and alkynyl groups may be straight-chain or branched, and the hydrogen atoms of the methyl or ethyl groups contained in the definitions may be wholly or partly replaced by fluorine atoms, or a tautomer, enantiomer, diastereomer, mixture thereof, or salt thereof.
 2. The compound of formula I according to claim 1, wherein R¹ denotes a methyl group substituted by a group R_(a), where R_(a) denotes a 3,4-dihydro-quinolinyl group, a 3,4-dihydro-isoquinolinyl group, a 1,4-dihydro-quinazolinyl or 4-oxo-1,4-dihydro-quinazolinyl group, a 3,4-dihydro-quinazolinyl or 4-oxo-3,4-dihydro-quinazolinyl group, a 1H-benzo[d][1,2]oxazinyl or 1-oxo-1H-benzo[d][1,2]oxazinyl group, a 4H-benzo[e][1,3]oxazinyl or 4-oxo-4H-benzo[e][1,3]oxazinyl group, a 4H-benzo[d][1,3]oxazinyl or 4-oxo-4H-benzo[d][1,3]oxazinyl group, a 2H-benzo[1,4]oxazinyl or 2-oxo-2H-benzo[1,4]oxazinyl group, a 4H-benzo[e][1,3]thiazinyl or 4-oxo-4H-benzo[e][1,3]thiazinyl group, a 4H-benzo[d][1,3]thiazinyl or 2H-benzo[1,4]thiazinyl group, a 2-oxo-2H-benzo[e][1,3]oxazinyl or 2,2-dioxo-1H-benzo[c][1,2]thiazinyl group, a 2,3-dihydro-1H-benzo[e][1,4]diazepinyl or 2-oxo-2,3-dihydro-1H-benzo[e][1,4]diazepinyl group, a 4,5-dihydro-3H-benzo[b][1,4]diazepinyl or 4-oxo-4,5-dihydro-3H-benzo[b][1,4]diazepinyl group, a 5-oxo-4,5-dihydro-3H-benzo[e][1,4]diazepinyl group, a 2,3-dihydro-benzo[f][1,4]oxazepinyl or 2,3-dihydro-benzo[b][1,4]oxazepinyl group, a 2,3-dihydro-benzo[f][1,4]thiazepinyl or 2,3-dihydro-benzo[b][1,4]thiazepinyl group, a 5-oxo-4,5-dihydro-benzo[f][1,3,4]oxadiazepinyl group, a 11H-dibenzo[b,e]azepinyl or 11-oxo-11H-dibenzo[b,e]azepinyl group, a 11H-benzo[e]pyrido[3,2-b]azepinyl or a 5H-1,9,10-triaza-dibenzo[a,d]-cycloheptenyl group, a 5H-dibenzo[b,e][1,4]diazepinyl or dibenzo[b,f][1,4]oxazepinyl group, a dibenzo[b,f][1,4]thiazepinyl, 5-oxo-dibenzo[b,f][1,4]thiazepinyl or 5,5-dioxo-dibenzo[b,f][1,4]thiazepinyl group, a 5H-dibenzo[a,d]cycloheptenyl or 5H-dibenzo[b,f]azepinyl group, a phenanthridinyl, benzo[c][1,5]naphthyridinyl, benzo[h][1,6]naphthyridinyl, benzo[c][1,8]naphthyridinyl, benzo[f][1,7]naphthyridinyl or 1,5,9-triaza-phenanthrenyl group, a 1,2,3,4-tetrahydro-phenanthridinyl, 1,2,3,4,4a,10b-hexahydro-phenanthridinyl, 2,3-dihydro-1H-4-aza-cyclopenta[a]naphthyl or 8,9,10,11-tetrahydro-7H-6-aza-cyclohepta[a]naphthyl group, a 2,3-dihydro-1H-4-oxa-10-aza-phenanthrenyl or 1-oxo-2,3-dihydro-1H-4-oxa-10-aza-phenanthrenyl group, a phenanthrenyl, benzo[h]quinolinyl, benzo[f]quinolinyl or benzo[f]quinoxalinyl group, a 5H-benzo[e]pyrrolo[1,2-a][1,4]diazepinyl, thieno[3,2-b][1,4]benzoxazepinyl, 5H-dibenzo[d,f][1,3]diazepinyl or 5-oxa-7-aza-dibenzo[a,c]cycloheptenyl group, a naphtho[1,2-d]oxazolyl, naphtho[2,1-c]oxazolyl, naphtho[1,2-d]thiazolyl, naphtho[2,1-c]thiazolyl, naphtho[1,2-d]imidazolyl, naphtho[1,2-b]furanyl or naphtho[2,1-b]furanyl group, or a furo[3,2-c]isoquinolinyl, pyrazolo[1,5-c]quinazolinyl or 1H-perimidinyl group, while the benzo groups of the above mentioned radicals R_(a) are substituted by the groups R¹⁰ to R¹³ and the alkylene units of the above mentioned groups R_(a) may be substituted by one or two fluorine atoms or one or two C₁₋₃-alkyl or C₁₋₃-alkyloxy-carbonyl groups and the imino groups of the above mentioned radicals R_(a) may be substituted by a C₁₋₃-alkyl group and R¹⁰ denotes a hydrogen atom, a fluorine, chlorine, bromine or iodine atom, a C₁₋₃-alkyl or cyclopropyl group, a hydroxy, C₁₋₃-alkyloxy or cyclopropyloxy group, a nitro, amino, C₁₋₃-alkylamino or di-(C₁₋₃-alkyl)amino group, a C₁₋₃-alkyl-carbonylamino or C₁₋₃-alkyl-sulphonylamino group, a cyano, carboxy, C₁₋₃-alkyloxy-carbonyl, aminocarbonyl, C₁₋₃-alkyl-aminocarbonyl or di-(C₁₋₃-alkyl)-aminocarbonyl group, a mercapto, C₁₋₃-alkylsulphanyl, C₁₋₃-alkysulphinyl, C₁₋₃-alkylsulphonyl or aminosulphonyl group or a difluoromethyl, trifluoromethyl, difluoromethoxy or trifluoromethoxy group and R¹¹, R¹² and R¹³, which may be identical or different, in each case represent a hydrogen atom, a fluorine, chlorine or bromine atom, a methyl, trifluoromethyl or methoxy group, R² denotes a hydrogen atom or a C₁₋₃-alkyl, cyclopropyl or trifluoromethyl group, Y denotes a group of formula C—R⁵, while R⁵ denotes a hydrogen atom or a C₁₋₃-alkyl group, R³ denotes a 2-buten-1-yl or 3-methyl-2-buten-1-yl group, a 1-buten-1-yl group, or a 2-butyn-1-yl group and R⁴ denotes a (3-amino-piperidin-1-yl) group, while, unless otherwise stated, the above mentioned alkyl groups may be straight-chain or branched, or a tautomer, enantiomer, diastereomer, mixture thereof, or salt thereof.
 3. The compound of formula I according to claim 2, wherein R¹ denotes a methyl group substituted by a group R_(a), where R_(a) denotes a 3,4-dihydro-quinolin-2-yl group, a 3,4-dihydro-isoquinolin-1-yl group, a 1,4-dihydro-quinazolin-2-yl or 4-oxo-1,4-dihydro-quinazolin-2-yl group, a 3,4-dihydro-quinazolin-2-yl or 4-oxo-3,4-dihydro-quinazolin-2-yl group, a 1H-benzo[d][1,2]oxazin-4-yl or 1-oxo-1H-benzo[d][1,2]oxazin-4-yl group, a 4H-benzo[e][1,3]oxazin-2-yl or 4-oxo-4H-benzo[e][1,3]oxazin-2-yl group, a 4H-benzo[d][1,3]oxazin-2-yl or 4-oxo-4H-benzo[d][1,3]oxazin-2-yl group, a 2H-benzo[1,4]oxazin-3-yl or 2-oxo-2H-benzo[1,4]oxazin-3-yl group, a 4H-benzo[e][1,3]thiazin-2-yl or 4-oxo-4H-benzo[e][1,3]thiazin-2-yl group, a 4H-benzo[d][1,3]thiazin-2-yl or 2H-benzo[1,4]thiazin-3-yl group, a 2-oxo-2H-benzo[e][1,3]oxazin-4-yl or 2,2-dioxo-1H-benzo[c][1,2]thiazin-4-yl group, a 2,3-dihydro-1H-benzo[e][1,4]diazepin-5-yl or 2-oxo-2,3-dihydro-1H-benzo[e][1,4]diazepin-5-yl group, a 4,5-dihydro-3H-benzo[b][1,4]diazepin-2-yl or 4-oxo-4,5-dihydro-3H-benzo[b][1,4]diazepin-2-yl group, a 5-oxo-4,5-dihydro-3H-benzo[e][1,4]diazepin-2-yl group, a 2,3-dihydro-benzo[f][1,4]oxazepin-5-yl or 2,3-dihydro-benzo[b][1,4]oxazepin-4-yl group, a 2,3-dihydro-benzo[f][1,4]thiazepin-5-yl or 2,3-dihydro-benzo[b][1,4]thiazepin-4-yl group, a 5-oxo-4,5-dihydro-benzo[f][1,3,4]oxadiazepin-2-yl group, a 11H-dibenzo[b,e]azepin-6-yl or 11-oxo-11H-dibenzo[b,e]azepin-6-yl group, a 11H-benzo[e]pyrido[3,2-b]azepin-6-yl or a 5H-1,9,10-triaza-dibenzo[a,d]-cyclohepten-11-yl group, a 5H-dibenzo[b,e][1,4]diazepin-11-yl or dibenzo[b,f][1,4]oxazepin-11-yl group, a dibenzo[b,f][1,4]thiazepin-11-yl, 5-oxo-dibenzo[b,f][1,4]thiazepin-11-yl or 5,5-dioxo-dibenzo[b,f][1,4]thiazepin-11-yl group, a 5H-dibenzo[a,d]cyclohepten-10-yl or 5H-dibenzo[b,f]azepin-10-yl group, a phenanthridin-6-yl, benzo[c][1,5]naphthyridin-6-yl, benzo[h][1,6]naphthyridin-5-yl, benzo[c][1,8]naphthyridin-6-yl, benzo[f][1,7]naphthyridin-5-yl or 1,5,9-triaza-phenanthren-10-yl group, a 1,2,3,4-tetrahydro-phenanthridin-6-yl, 1,2,3,4,4a, 10b-hexahydro-phenanthridin-6-yl, 2,3-dihydro-1H-4-aza-cyclopenta[a]naphth-5-yl or 8,9,10,11-tetrahydro-7H-6-aza-cyclohepta[a]naphth-5-yl group, a 2,3-dihydro-1H-4-oxa-10-aza-phenanthren-9-yl or 1-oxo-2,3-dihydro-1H-4-oxa-10-aza-phenanthren-9-yl group, a phenanthren-9-yl, benzo[h]quinolin-6-yl, benzo[f]quinolin-6-yl or benzo[f]quinoxalin-6-yl group, a 5H-benzo[e]pyrrolo[1,2-a][1,4]diazepin-11-yl, thieno[3,2-b][1,4]benzoxazepin-9-yl, 5H-dibenzo[d,f][1,3]diazepin-6-yl or 5-oxa-7-aza-dibenzo[a,c]cyclohepten-6-yl group, a naphtho[1,2-d]oxazol-2-yl, naphtho[2,1-d]oxazol-2-yl, naphtho[1,2-d]thiazol-2-yl, naphtho[2,1-d]thiazol-2-yl, naphtho[1,2-d]imidazol-2-yl, naphtho[1,2-b]furan-2-yl or naphtho[2,1-b]furan-2-yl group, or a furo[3,2-c]isoquinolin-5-yl, pyrazolo[1,5-c]quinazolin-5-yl or 1H-perimidin-2-yl group, while the benzo groups of the above mentioned radicals R_(a) are substituted by the groups R¹⁰ to R¹³ and the alkylene units of the above mentioned groups R_(a) may be substituted by one or two fluorine atoms or one or two methyl groups and the imino groups of the above mentioned radicals R_(a) may be substituted by a methyl group and R¹⁰ denotes a hydrogen atom, a fluorine, chlorine, bromine or iodine atom, a methyl or ethyl group, a hydroxy, methoxy or ethoxy group or a difluoromethyl, trifluoromethyl, difluoromethoxy, or trifluoromethoxy group and R¹¹, R¹² and R¹³, which may be identical or different, each denote a hydrogen, fluorine, chlorine or bromine atom or a methyl, trifluoromethyl or methoxy group, R² denotes a hydrogen atom or a methyl, trifluoromethyl, ethyl, propyl, cyclopropyl or isopropyl group, Y denotes a group of formula C—R⁵, while R⁵ denotes a hydrogen atom or a methyl, ethyl, propyl or isopropyl group, R³ denotes a 2-buten-1-yl or 3-methyl-2-buten-1-yl group, a 1-buten-1-yl group, or a 2-butyn-1-yl group and R⁴ denotes a (3-amino-piperidin-1-yl) group, or a tautomer, enantiomer, diastereomer, mixture thereof, or salt thereof.
 4. A physiologically acceptable salt of the compound according to claim 1 with an inorganic or organic acid.
 5. A pharmaceutical composition containing a compound according to claim 1 or a salt with an inorganic or organic acid optionally together with one or more inert carriers and/or diluents. 